Formulation Development and Evaluation of Ondansetron Hydrochloride sustained release Matrix tablets
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2009, Vol 1, Issue 4
Abstract
The objective of the present study was to develop sustained release matrix tablets of Ondansetron hydrochloride [5mg] formulated employing Hydroxy Propyl Methyl Cellulose polymer and the sustained release behaviour of the tablets was investigated. Tablets were prepared by wet granulation methods. The granules were evaluated for angle of repose, bulk density and drug content .The tablets were subjected to thickness, diameter, weight variation test, hardness, friability, drug content and in vitro release studies. Formulation was optimized onthe basis of acceptable tablet properties and in vitro drug release. The results of dissolution studies indicated that formulation FV (drug to polymer ratio 1:3) the most successful of the study, exhibited drug release pattern very close to theoretical release profile. All the formulations (except FV) exhibited diffusion – dominated drug release. The mechanism of drug release from FV was diffusion coupled with erosion.
Authors and Affiliations
A. Anton Smith , A. Kottai Muthu , Wagh Bhushan Pandit Rao , R. Manavalan
Keywords
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