Formulation Development and Evaluation of Ondansetron Hydrochloride sustained release Matrix tablets
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2009, Vol 1, Issue 4
Abstract
The objective of the present study was to develop sustained release matrix tablets of Ondansetron hydrochloride [5mg] formulated employing Hydroxy Propyl Methyl Cellulose polymer and the sustained release behaviour of the tablets was investigated. Tablets were prepared by wet granulation methods. The granules were evaluated for angle of repose, bulk density and drug content .The tablets were subjected to thickness, diameter, weight variation test, hardness, friability, drug content and in vitro release studies. Formulation was optimized onthe basis of acceptable tablet properties and in vitro drug release. The results of dissolution studies indicated that formulation FV (drug to polymer ratio 1:3) the most successful of the study, exhibited drug release pattern very close to theoretical release profile. All the formulations (except FV) exhibited diffusion – dominated drug release. The mechanism of drug release from FV was diffusion coupled with erosion.
Authors and Affiliations
A. Anton Smith , A. Kottai Muthu , Wagh Bhushan Pandit Rao , R. Manavalan
Keywords
Related Articles
- EP ID EP123925
- DOI -
- Views 124
- Downloads 0
Anti-inflammatory and Analgesic activity of mature leaves methanol extract of Clerodendrum inerme L. (Gaertn)
Clerodendrum inerme is a hedge plant belongs to the Verbenaceae family, traditionally used for ornamental purpose in home gardens. In the present study, anti-inflammatory and analgesic effect of methanol extract of Clero...
Formulation and Evaluation of Piroxicam dispersible tablets using Natural disintegrants
The objective of necessary work to develop Piroxicam dispersible tablets using natural disintegrants which would release the drug rapidly with predetermined rate. Six batches of Piroxicam dispersible tablets were&nb...
New RP - HPLC Method for the Determination of Valproic acid in Human Plasma
A simple reverse phase HPLC method was developed for the determination of Valproic acid present in human plasma. A Denali, Grace, C18, 4.6 X 150mm, 5µ in an isocratic mode with mobile phase containing 40mM Ammonium dihyd...
Antioxidant Activity of Some Substituted 1, 2, 4 - Triazo-5-thione Schiff base
Series of Schiff’s bases of 3-substituted 1, 2, 4 triazo -5 thione (4a-e) were synthesized from the ester of methyl paraben. The structure of the newly synthesized compounds were confirmed by IR, 1HNMR and Mass spectrum....
Thin Layer Chromatodraphy Method for the Determination of Ternary Mixture Containing Salbutamol Sulphate, Bromhexine Hydrochloride and Etofylline
Simple, rapid, accurate, precise, reliable and economical thin layer chromatographic and spectrophotometric methods have been proposed for the resolution and determination of Salbutamol sulphate (SS), Brombexine hydrochl...