Formulation development and invitro evaluation of fentanyl patches for transdermal drug delivery system
Journal Title: Journal of Pharmaceutical and Biological Sciences - Year 2017, Vol 5, Issue 5
Abstract
Oral drug delivery system has various drawbacks like poor bioavailability due to hepatic metabolism (first pass) and the tendency to produce rapid blood level spikes (both high and low), leading to a need for high and frequent dosing, which can be both cost prohibitive and inconvenient. In present study transdermal drug delivery of Fentanyl was developed to overcome the first pass metabolism and to reduce frequency of dosing compared to oral route. Matrix type of transdermal patches were developed by using polymers Eudragit-L100, HPMC K4M and HPMC K15M. Transdermal patches were prepared by employing solvent casting method. Propylene glycol and Tween80 were selected as permeation enhancer and plasticizer. Formulations were prepared with the varying concentrations polymers ranging from F1-F6, and all the formulations were evaluated for various physical parameters, invitro drug release studies by using dialysis membrane. Among all the formulations F6 formulation was found to be best and shown 96.97% drug release in 12 hours. For F6 formulation release kinetics was applied and it was observed that the formulation was following peppas mechanism of drug release. Drug excipients compatibility studies were carried out by using FT-IR and it was observed that they were no interactions.
Authors and Affiliations
K. Sandhya Rani, Sunil Reddy, A. Venkatesham
Keywords
Related Articles
- EP ID EP322178
- DOI -
- Views 157
- Downloads 0
Epidemic history of hepatitis C virus, Prevalence and potential transmission risks in Punjab, Pakistan
Hepatitis C virus (HCV) was first identified in 1989 and belongs to the Flaviviridae family. It is a single-stranded RNA virus and has a long lag time between onset of infection and clinical manifestation of liver diseas...
Evaluating Waste Management in Selected Hospitals of Isfahan City in 2016
Objective: Hospital wastes have a special sensitivity due to containing dangerous, toxicant and pathogenic factors such as pathologic, infectious, medicinal, chemical and radioactive wastes. This study was conducted with...
Isolation, identification, enumeration and antibiotic profiling of microbes from soil contaminated with hospital waste dumbing
Hospital waste is a potential health hazards to the health care workers and public acquired infection, transfusion transmitted diseases. Increasing land and water pollution lead to increasing possibility of contracting m...
Toxicological evaluation of the aqueous extract of Pseudocedrela kotschyi (Meliaceae) stem bark in albino rats
Pseudocedrela kotschyi is a monoiceous plant used traditionally to treat many diseases. The present work has been designed to evaluate the toxicological profile of aqueous extract of Pseudocedrela kotschyi stem bark in e...
Evaluation of antidiabetic activity of ethanolic extract of roots of pterocarpus marsupium in streptozotocin induced diabetic rats
The present study evaluates the effect of ethanolic bark extract of P.marsupium in streptozotocin induced diabetic rats. Diabetes was induced in rats by administering streptozotocin (50mg/ kg) intraperitonially (ip). Ani...