FORMULATION, DEVELOPMENT AND STANDARDIZATION OF AN AYURVEDIC MUCO-ADHESIVE EXTENDED RELEASE VAGINAL TABLET
Journal Title: International Journal of Pharmacognosy - Year 2018, Vol 5, Issue 1
Abstract
The study aims to standardize a vaginal herbal formulation consisting of stem barks of Ficus glomerata Roxb. and Symplocos racemosa Roxb. Since they are used as Ayurvedic medicine and described in ancient text Charak Samhita as astringent, anti-inflammatory and treatment of vaginitis / leucorrhoea. This new herbal formulation is likely to exhibit significant antimicrobial action due to presence of phenolic and flavonoidic compounds. The extractive value was 1.64 and 1.70% w/w for aqueous and alcoholic extract. Total Phenol Content was 225.67 and 220.00 µg Gallic acid equivalent / mg for aqueous and alcoholic extract. Fifteen types of muco-adhesive tablets weighing 550, 700 or 900 mg each were prepared using combinations of research drug, Carbopol and Hydroxy-Propyl-Methyl Cellulose as polymers, talc as glidant, magnesium stearate as lubricant and Micro-Crystalline Cellulose and Lactose monohydrate as diluents. Similarly, five types of effervescent muco-adhesive tablets using sodium bicarbonate and citric acid in 3:1 ratio were prepared. Apart from weight, thickness, hardness and friability of each group, the surface pH, swelling index and muco-adhesive force were determined. The formulation F-XII provides best physical parameters of hardness (6.0 ± 2.53 kg/sq.cm), pH value (4.80 ± 0.04), swelling index (69.39 ± 0.44 % w/w) and muco-adhesive force (0.667 ± 0.02 Newton) which indicate its sustained slow releasing of anti-vaginitis drug delivery as an effective muco-adhesive vaginal tablet.
Authors and Affiliations
Mradu Gupta et al.
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