Formulation of the Model Fluconazole Eye Drop and Its Comparison with the Available Fluconazole Eye Drops
Journal Title: Indonesian Journal of Clinical Pharmacy - Year 2012, Vol 1, Issue 1
Abstract
The aim of the study was to formulate the model formulation of fluconazole eye drop and then compare it with the available eye drops. The corneal permeation studies were conducted using freshly excised sheep cornea, mounted between donor and receptor. The receptor cell had an internal volume of 11 mL, containing ringer bicarbonate (pH 7.4, 34±1 °C). At appropriated intervals 2 ml. samples were withdrawn from the side arm and were analyzed spectrophotometrically by measuring absorbance at λmax of 260 nm. Each experiment was continued for about 2.0 hrs (triplicate). At the end of the experiment, each cornea (freed from sclera) was weighed, soaked in 1 mL. methanol, dried overnight at 90 °C and reweighed. From the difference in weights corneal hydration was calculated. Even though, the marketed formulation (Zocon) comprised of 0.3% w/v of fluconazole and our model formulation contained only 0.2% w/v of fluconazole, the amount of fluconazole permeated from model formulation and the marketed formulation was respectively 78.34±4.26 and 22.14±1.3. The permeation from model formulation was much greater than other preparations and shows less corneal hydration (80.29±0.47) than others available preparations.
Authors and Affiliations
Sunil Thakral, Munish Ahuja
Keywords
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