FORMULATION, OPTIMIZATION AND IN VITRO EVALUATION OF RIFAMPICIN NANOEMULSIONS
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2015, Vol 7, Issue 6
Abstract
The aim of the present investigation was to develop, optimize and evaluate nanoemulsion of rifampicin to improve the solubility, stability and oral bioavailability. Rifampicin nanoemulsions were prepared by o/w nanoemulsion region of the phase diagrams, which were subjected to physical stability and phase separation tests. Prepared rifampicin nanoemulsions were evaluated for particle size, zeta potential, PDI and drug content. In vitro dissolution was performed by using dialysis bag method and morphology by transmission electron microscopy (TEM). Best results were obtained with the formulation which consisted of 10 mg of rifampicin, 15% w/w of sefsol 218, 25% w/w of tween 80, 15% w/w of tween 20 and 45% w/w of water. In vitro release studies revealed that 99.85 ± 1.85% was observed in 12h. TEM studies shows the globules are in spherical shape with dark surroundings. DSC studies revealed that no interaction between the drug and excipients. The optimized formulation was also subjected to stability studies according and was found to be stable for one month with no phase separation. These results indicated the potential of nanoemulsions of rifampicin could be promising to improve solubility, stability and oral bioavailability.
Authors and Affiliations
Aruna Devi Mantena, Basava Raju Dontamsetti, Archana Nerella
Keywords
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