FREE RADICAL SCAVENGING ACTIVITY OF VARIOUS EXTRACTS OF WHOLE PLANT OF Calycopteris floribunda (Lam.): AN IN-VITRO EVALUATION
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2015, Vol 8, Issue 2
Abstract
 Objective: The present research was subjected to screen the free radical scavenging activity of various extracts of whole plant of Calycopterisfloribunda by different in-vitro models.Methods: The antioxidant activity was evaluated by hydroxyl radical scavenging activity, nitric oxide radical scavenging activity with referencestandard ascorbate and total phenol content respectively.Results: An inhibitory concentration 50% (IC50) value was found ethyl acetate extract of C. floribunda is more effective in hydroxyl radical scavengingactivity than that of methanolic and petroleum ether extract. The IC50 values of ethyl acetate extract of C. floribunda and ascorbate were found to be530 μg/ml and 410 μg/ml respectively. The ethyl acetate extract of C. floribunda was found more effective in the nitric oxide scavenging activity. TheIC50 values of ethyl acetate extract of C. floribunda and ascorbate were found to be 570 μg/ml and 410 μg/ml respectively. But when compared to allthe three extracts with ascorbate (standard), the ethyl acetate extract of C. floribunda showed the better result. In addition, the ethyl acetate extract ofC. floribunda was found to contain a noticeable amount of total phenols, which play a major role in controlling antioxidants. The results were observedin a concentration dependent manner.Conclusion: Our findings revealed that ethyl acetate extract of C. floribunda possesses interesting antioxidant activity, which may provide productionagainst free radicals induced damage to biomolecules.Keywords: Calycopteris floribunda, Antioxidant, Ascorbate, Scavenging activity, Inhibitory concentration 50%.
Authors and Affiliations
Bhuvaneswari Santharam, Ganesh P, Soranam R, Packia Lekshmi
Keywords
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