FREQUENCY OF ANTIBODIES IN HAEMOLYTIC DISEASE OF FOETUS AND NEWBORN
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 66
Abstract
BACKGROUND Haemolytic disease of foetus and newborn (HDFN) is triggered by enhanced destruction of red blood cell due to immune-mediated destruction, intrinsic abnormalities, acquired aberrations, etc. Lifespan of infant’s erythrocytes are shortened by the action of placentally transferred maternal antibodies in immune-mediated HDFN. The aim of this study was to identify the frequency of maternal antibodies in neonates with hyperbilirubinaemia. Settings and Design- This was a cross-sectional study in neonates admitted to neonatal intensive care unit (NICU). Setting for the research was Dept. of Transfusion Medicine and Neonatology division of Sree Avittom Thirunal Hospital for women and children attached to Govt. Medical College, Trivandrum. MATERIALS AND METHODS Demographic details and maternal details were recorded. Cause for hyperbilirubinaemia was noted down and it was classified by AAP chart. Maternal antibody-mediated hyperbilirubinaemia was diagnosed according to inclusion criteria. RESULTS 2619 neonates were admitted in NICU. 340 infants were admitted for treatment of hyperbilirubinaemia. Among them, 158 (6%) had hyperbilirubinaemia due to HDFN and 182 (7%) had hyperbilirubinaemia due to other causes. The rest 2279 (87%) had other ailments. Five categories of red cell antibodies were found in HDFN. Anti-A (58.2%), anti-B (11.4%), anti-D (27.8%), anti-c (1.3%) and anti-E (1.3%). All mothers of infants with ABO-HDFN were having O blood group. No antibodies outside ABO or Rh blood group systems were detected. Statistical Analysis- All statistical data were analysed using SPSS software version 16. CONCLUSION HDFN is an important cause for hyperbilirubinaemia in neonates. ABO haemolytic disease was commoner and Group A or B neonates born to O Group mothers were at risk for HDFN. Rh HDFN due to anti-D is common than other clinically significant Rh antibodies.
Authors and Affiliations
Sajith Vilambil, Meena Dharmadas, Kumari Krishnakumariamma Chakrapani Usha, Shaiji Panthiyil Shahulhameed, Chitra James, Anjaly Padmavilas Sasikala, Soonam John, Vineeth Rajagopal
Keywords
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- EP ID EP231716
- DOI 10.14260/Jemds/2017/1029
- Views 97
- Downloads 0
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