Frequency of Hepatotoxicity in Pulmonary Tuberculosis Patients taking Anti-Tuberculosis Therapy
Journal Title: UNKNOWN - Year 2017, Vol 1, Issue 2
Abstract
Abstract Background: Tuberculosis is a global pandemic which affects millions of people every year. The treatment of tuberculosis consists of simultaneous use of several drugs for a prolonged period of time, therefore anti-tuberculosis treatment induced toxicity is a real problem. It is the most common side effect leading to interruption of therapy. Wide variations have been found in the reported incidence of hepatotoxicity during short-course chemotherapy. This study was conducted to determine the frequency of ATT induced hepatotoxicity in pulmonary TB patients. Methodology: This descriptive, cross-sectional study was conducted at Gulab Devi Chest Hospital Lahore from November 2015 to January 2016. Total 137 pulmonary TB patients were included in this study according to inclusion and exclusion criteria. Data of patients was collected by Questionnaire. Blood samples were taken and LFTs were done. Data was analyzed by using SPSS version 16. Results: Data of 137 patients was taken in the study. Out of which 60 (43.8%) were male and 77 (56.2%) were female. The mean age was 40.59±16.57. 45 (32.8%) patients out of 137, develop hepatotoxicity while 92 (67.2%) shows normal patterns of liver function. 22 (16.1%) patients out of 137 showed elevation of serum bilirubin levels. Conclusion: ATT induced hepatotoxicity is a frequent complication in Pulmonary Tuberculosis patients. So, all patients put on ATT must be followed up for at least the initial month. The patients and the treating physicians must be well-educated about the adverse effects of the ATT, its early recognition and management.
Authors and Affiliations
Farkhanda Noureen, Abdur Rehman, Asif Hanif
Keywords
Related Articles
- EP ID EP648198
- DOI 10.5281/zenodo.2545898
- Views 149
- Downloads 0
CPEC and Healthcare Benefits
China-Pakistan Economic Corridor (CPEC) is a bond of bilateral cooperation between China and Pakistan to enhance economic growth of both the countries. As far as Pakistan is concerned, CPEC is one of the supreme strategi...
Association of Hyperuricemia with Coronary Artery Disease in Gulab Devi Chest Hospital
Background: Coronary artery disease is the most common and life threatening cardiac emergency presenting to a hospital. Having significant mortality and morbidity are on the rise in Pakistan. The objective of the study i...
Preface to The International Journal of Frontier Sciences
Hundreds of thousands of research papers are published every year all over the world. Scientists give their best in the field of research. Every researcher has a valuable contribution to scientific knowledge and ultimate...
Association of Risk Factors of Ectopic Pregnancy
Background: Ectopic pregnancy is the implantation of a fertilized ovum anywhere outside the uterine cavity. Around 95% of ectopic pregnancies occur in the Fallopian tubes. Most of these are occurring in the ampulla regio...
Water: The Elixir of Life
Water is a chemical compound made up of two elements, Hydrogen gas, which is combustible and Oxygen gas, which causes to burn. But the union of two atoms of Hydrogen and one atom of Oxygen results in a colourless and odo...