Frozen embryo transfer prevents the detrimental effect of high estrogen on endometrium receptivity
Journal Title: UNKNOWN - Year 2017, Vol 18, Issue 1
Abstract
Objective: To investigate whether serum levels of estradiol affect reproductive outcomes of normoresponder women undergoing fresh embryo transfer (ET) versus frozen-thawed ET (FET). Material and Methods: Two hundred fifty-five normoresponder women underwent fresh ET in their first or second in vitro fertilization cycle. Ninety-two women with negative pregnacy test results underwent FET. Clinical and ongoing pregnancy rates, implantation, and live birth rates of women undergoing fresh ET versus FET were compared. Results: One hundred forty-seven (57.65%) out of the 255 normoresponder women receiving FET had positive beta-human chorionic gonadotrophin (hCG) results. The remaining 108 women had negative beta-hCG results. The clinical pregnancy rates of the fresh ET group were found as 55.69% (n=142). Ninety-two of the 108 women with failed pregnancies underwent FET; 72.83% had positive beta-hCG results (n=67), and 70.65% had clinical pregnancy (n=65). Both biochemical and clinical pregnancy rates of women undergoing FET increased significantly (p<0.012 and p<0.013, respectively). Ongoing pregnancy (60.87% vs. 52.94%) and live birth rates (59.87% vs. 48.63%) were similar in both fresh and FET groups. Serum E2 levels of women who failed to conceive were significantly higher than those women did conceive. Serum progesterone levels of women who conceived versus those that did not were similar. Conclusion: The detrimental effect of high serum estradiol levels on endometrial receptivity could be prevented by FET.
Authors and Affiliations
Aynur Adeviye Erşahin, Mustafa Acet, Suat Süphan Erşahin, Nur Dokuzeylül Güngör
Keywords
Related Articles
- EP ID EP379891
- DOI 10.4274/jtgga.2016.0186
- Views 67
- Downloads 0
Ovarian cancer: Pathogenesis and current recommendations for prophylactic surgery
Ovarian cancer is one of the most common gynecologic cancers, and one of the leading causes of cancer-associated female mortality in the world. Currently, no widely accepted pathogenesis is available, which may explain t...
Are the skin scar characteristics and closure of the parietal peritoneum associated with pelvic adhesions?
Objective: To assess whether the abdominal scar characteristics and closure of the peritoneum were associated with pelvic adhesions. Materials and Methods: Patients who had undergone cesarean section between December 20...
Selective fetal reduction in monochorionic twins: Preliminary experience
Objective: In complicated mono-chorionic twin pregnancies, vaso-occlusive techniques like bipolar cord coagulation (BPCC), radiofrequency ablation (RFA), interstitial laser ablation (ILA) of cord and fetoscopy guided cor...
Natural cycle versus artificial cycle in frozen-thawed embryo transfer: A randomized prospective trial
Objective: To investigate whether there was a difference in pregnancy outcomes between modified natural cycle frozen-thawed embryo transfer (NC-FET) cycles and artificial cycles (AC)-FET in women who all had regular mens...
Decoding stillbirths using the Relevant Condition at Death classification: Study from the developing world
Objective: To determine the stillbirth rate in 2017 at Christian Medical College, a tertiary care perinatal center in South India, and to identify causes for the various stillbirths that occurred using the Relevant Condi...