Functional cure of chronic hepatitis B is not a dream
Journal Title: Journal of Clinical Hepatology - Year 2025, Vol 41, Issue 1
Abstract
Functional cure of chronic hepatitis B (CHB) is defined as HBsAg<0.05 IU/mL and serum HBV DNA<10 IU/mL for at least 24 weeks after discontinuation of antiviral therapy. This requires suppression of HBV replication and reduction of viral antigen production, as well as restoration of immune response to HBV infection. About 30% — 50% of highly selected CHB patients treated with nucleos(t)ide analogues can achieve functional cure after add-on therapy or monotherapy with pegylated interferon-α or a finite course of treatment with nucleos(t)ide analogues among patients with HBsAg<100 IU/mL. At present, clinical trials are being conducted for more than 40 types of novel anti-HBV drugs and immunomodulators. The combination of drugs that inhibit viral replication, reduce antigen burden, and restore immune response to HBV infection may be an ideal strategy to achieve the functional cure of CHB. However, further studies are needed to determine the optimal drug combination, the timing and sequence of medication, and the duration of treatment.
Authors and Affiliations
Hui ZHUANG
Evaluation and management of nutritional consequences in patients with alcoholic cirrhosis
Patients with alcoholic cirrhosis often experience varying degrees of malnutrition, and the patients with malnutrition are more susceptible to complications such as infections and ascites, which may lead to a poor prog...
Expert consensus on precision detection of intrahepatic cholangiocarcinoma (2024 edition)
Intrahepatic cholangiocarcinoma (ICC) is a highly heterogeneous tumor, and molecular profiling serves as the foundation for personalized treatment of ICC. Accurate detection methods are clinically significant for comp...
Driving innovation and fostering collaboration to advance the development and clinical research of next-generation human serum albumin
Albumin is the most abundant protein in human plasma, and in addition to the function of maintaining plasma colloid osmotic pressure, it also has the functions of material transport, detoxification, maintaining vascu...
The development and application of genetically engineered human serum albumin
Human serum albumin (HSA) is the most abundant protein in plasma and has many biological functions and clinical applications. An adequate and stable supply of functional HSA molecules that are easy to store and have a...
Mechanism of cuproptosis and its role in liver diseases
Cuproptosis is a new type of cell death that depends on intracellular copper accumulation to trigger the aggregation of mitochondrial lipoacylated protein and the degradation of iron-sulfur cluster protein, with a diffe...