Galleria mellonella L. as model organism used in biomedical and other studies / Galleria mellonella L. – organizm modelowy stosowany w badaniach biomedycznych i innych
Journal Title: Przegląd Epidemiologiczny - Year 2018, Vol 72, Issue 1
Abstract
Comparative of studies of genomes of invertebrates and humans shows that in invertebrates including insects there are numerous homologues of human’s genes coding proteins involved in recognition pathogens or transduction of the expression signal. Thanks this features, insects such as Drosophila melanogaster M., Blattella germanica L., Culex quinquefasciatus S., Bombyx mori L. and Galleria mellonella L. are used in studies on virulence, host resistance or in assessing the in vivo efficacy of antibiotics, fungicides and other biologically active substances. G. mellonella (greater wax moth) are rapid growth, high fertility, size and short life cycle insects- these are features that should be met by good model organisms; therefore the number of researches with larvae of wax moth as the model organism for pathogens assays grows from year to year. This is showing by number of scientific publications about infection’s model of G. mellonella. An obstacle in the wide use of G. mellonella caterpillars as a model in biomedical research is the lack of standardized breeding of these insects, which would guarantee the reproducibility of the obtained results and lack of procedures and standards according to which biomedical research will be carried out. Despite this, the G. mellonella model can be used in the initial analysis before conventional in vivo tests and to reduce the number of tests performed on mammals.
Authors and Affiliations
Ewa Mikulak, Aleksandra Gliniewicz, Marta Przygodzka, Jolanta Solecka
Keywords
Related Articles
- EP ID EP625367
- DOI -
- Views 76
- Downloads 0
Neoerlichioza – nowa choroba odkleszczowa – czy stwarza zagrożenie w Polsce?
W ciągu ostatnich lat w kilku krajach europejskich zidentyfikowano nowy patogen przenoszony przez kleszcze Ixodes ricinus Candidatus Neoehrlichia mikurensis. Jest to Gram ujemna wewnątrzkomórkowa bakteria należąca do rod...
Production of extracellular polysaccharide and biofilm under different oxygen conditions by clinical isolates of Staphylococcus aureus non-susceptible to glycopeptides / Produkcja zewnątrzkomórkowego mukopolisacharydu oraz biofilmu w warunkach zróżnicowanej dostępności tlenu przez kliniczne izolaty Staphylococcus aureus niewrażliwe na glikopeptydy
INTRODUCTION: Staphylococcus aureus, which is able to produce an extracellular mucopolysaccharide (MP) and biofilm (SP), is an important etiologic agent in persistent and implant-related infections. This phenotype may be...
Importance of financial liquidity in hospital management /Znaczenie płynności finansowej w zarzadzaniu szpitalem
INTRODUCTION: Financial liquidity management in hospitals is of great importance in ensuring access to medical care and continuity of health care service provision. It is one of the management’s biggest challenges, which...
Nationwide General Hospital Morbidity Study as a source of data about Polish population health / Ogólnopolskie Badanie Chorobowości Szpitalnej Ogólnej jako źródło danych o problemach zdrowia ludności Polski
The objective of this article is description of the important source of data on hospitalised morbidity collected in Poland within the frameworks of public statistics, and also underlying the significance of the quality o...
Rapid appraisal of road-safety environment around educational institutions of Mangaluru city, South India
INTRODUCTION: Road traffic accidents (RTA) are the biggest killers according to the Global Status Report on Road Safety. OBJECTIVE: The objective of the present study was to assess the road safety in the vicinity of the...