GARCINIA KOLA SEED AND VITAMIN E AMELIORATES ACETAMINOPHEN INDUCED OXIDATIVE STRESS IN ALBINO RATS
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2017, Vol 4, Issue 11
Abstract
Acetaminophen, a widely available drug used to treat fever and pains has been reported to exhibit toxic side effects. The study investigated the ameliorating effects of aqueous Garcinia kola seed extract and vitamin E on oxidative stress induced by acetaminophen in albino rats. The results showed that the acetaminophen induced rats were subjected to oxidative stress as was shown by the extent of lipid peroxidation (high malondialdehyde levels) and marked reduction of enzymatic antioxidants (superoxide dismutase, catalase and glutathione peroxidase) levels in the serum when compared with the control. Pretreatment with varied concentration of aqueous Garcinia kola seed extract (800mg/kg, 100mg/kg) and vitamin E (50mg/kg, 25mg/kg) by the oral gavage method for 7 days prior to acetaminophen intraperitoneal administration (800mg) resulted in significant decrease (p<0.05) of malondialdehyde level, increased levels of the activities of SOD, CAT and GPX in the serum thus resulting in reducing the free radicals formation in the blood of the rat. The combined form of pretreatment showed no synergistic effect when compared with the singly pretreatment with either Garcinia kola or vitamin E. These observations demonstrate that aqueous Garcinia kola seed extract and vitamin E possesses antioxidant properties that ameliorates oxidative stress induced by acetaminophen.
Authors and Affiliations
Waribo H. A.
Keywords
Related Articles
- EP ID EP631132
- DOI -
- Views 178
- Downloads 0
DEVELOPMENT AND ANTIMICROBIAL POTENTIAL OF SOAP BASED ON AQUEOUS EXTRACT OF LEAVES OF MORINDA MORINDOIDES (MORINDA, RUBIACEAE) AGAINST CUTANEOUS PATHOGENS.
Different extracts of leaves of Morinda morindoides (Baker) Milne-Redh (Rubiaceae) showed interesting in vitro antimicrobial activities against pathogenics involved in cutaneous infections. The purpose of this investigat...
THE BIO TOXICITY OF IN-SITU SYNTHESIZED CARBOXYLATED NANODIAMOND-IRON OXIDE NANOCOMPOSITE
Nanodiamond (ND) particles have potential applications in protein immobilization, biosensors, therapeutic molecule delivery and bio imaging. A nanocomposite comprises both high hardness of nanodiamond (ND) and high magne...
A LITERATURE REVIEW ON HYPERTENSIVE CRISIS
Hypertension (HTN) is a leading cause of global disease, mortality, and disability. In developed countries because of increased awareness regarding the health and widespread availability of antihypertensive drug, there h...
THE OUTCOME OF SURGICAL INTERVENTION OF MALIGNANT TUMORS OF MAXILLA
Malignant tumors of the maxilla and paranasal sinuses constitute less than 1% of whole malignant tumor of the body and about 3% of upper aerodigestive tract malignant tumor. Malignant tumors of maxilla are usually locall...
EFFECT OF OMEGA-3 ON CARDIAC MUSCLE STRUCTURE IN A MODEL OF RHEUMATOID ARTHRITIS IN RAT. A LIGHT AND ELECTRON MICROSCOPIC STUDY
Background: Rheumatoid arthritis (RA) is the most common form of chronic inflammatory arthritis. High percent of premature mortality in RA patients was largely attributable to cardiovascular diseases. Unfortunately, no c...