Gastrointestinal Stromal Tumors: Prevalence, Clinical Presentation, Management and their Outcome
Journal Title: International Journal of Interdisciplinary and Multidisciplinary Studies (IJIMS) - Year 2016, Vol 3, Issue 3
Abstract
Gastrointestinal stromal tumours (GIST) are the most common non-epithelial tumours of the gastrointestinal tract. Prediction of clinical behaviour based on morphologic features has been particularly difficult. Definitive surgery remains the treatment of choice for patients with localized GIST. The current study aims to analyze the prevalence, clinical presentation of GIST in a defined population, their management and outcome.The present prospective and retrospective observational study was conducted during the period of May 2013 to May 2015 in the Department of Surgery of NIMS Medical College & Hospital, Jaipur, India. A total of 30 confirmed patients of Gastrointestinal stromal tumors (Histopathology and CD117+) admitted under department of surgery were taken prospectively from June 2013 to June 2015 (2 years) and retrospectively from June 2010 to May 2013 (3 years). Data were recorded in Microsoft Excel sheet and then transferred and analyzed by SPSS 16.0 software using appropriate tests. The differences were considered to be significant at p-value < 0.05. Most common clinical presentation was abdominal pain (86.7%) followed by blood in stools, vomiting (56.7% and 53.3% respectively) and Hematemesis (26.7%).The prevalence of GIST, out of total GI malignancy was found to be 2.8% in present study. Most common clinical presentation was abdominal pain (86.7%) followed by blood in stools, vomiting (56.7% and 53.3% respectively) and Hematemesis (26.7%). As per the NIH criteria, 43.3% GIST were classified as high risk while 20% and 36.7% were of intermediate and low risk. Laparotomic surgical Resection along with chemotherapy was the most common management strategy employed for patients of GIST. Laparoscopic Resection was employed in 2 cases. Recurrence was observed in 1 case. Out of the 30 cases of GIST, 27 patients were alive till the follow up period, 2 cases were lost to follow up and a single mortality was observed.While GISTs continue to present a diagnostic and therapeutic challenge, our experience demonstrates the excellent oncologic outcomes and favourable safety profile that may be obtained, with increasing use of surgical resections and adjuvant chemotherapy (TKI).
Authors and Affiliations
Sanjay Chatterjee, Ashok K Gupta, Rituraj
Keywords
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