Gastroprotective Property of Psychotria luzoniensis Leaf Decoction on HCl/Ethanol-Induced Gastric Ulcers in Mice
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 1
Abstract
Psychotria luzoniensis, or more commonly known as “tagpong gubat”, is a speciose Psychotria that is believed to have gastroprotective property based on the ethnobotanical knowledge about the plant among Filipino natives. The purpose of this study was to validate the gastroprotective property of P. luzoniensis using 15 male Balb/c mice which were randomly divided into three groups wherein each was assigned with different treatments; induction of gastric ulceration was done by giving 0.5 ml of a solution containing 40% of 0.3M HCl and 60% of absolute ethanol. The first group was given 0.5 ml solution of 11.65 mg/ml of sucralfate; the second group received 0.5 ml of the Psychotria luconiensis decoction while the third group was given 0.5 ml of distilled water. Specimens were extracted, stained, and evaluated to assess the gastric ulceration. Random sampling and blind testing techniques were used to avoid bias and an arbitrary grading scale of zero to three was used during assessment of ulceration. Results showed significantly lower gastric ulcers in both the sucralfate (1.00 ± 0.71) and Psychotria luzoniensis decoction (0.60 ± 0.55) groups than in the distilled water group (2.75 ± 0.50) (p<0.05) grade. These findings showed that Psychotria luzoniensis decoction has a positive gastroprotective property in HCl/ethanol-induced gastric ulcers in mice.
Authors and Affiliations
Allan L. Hilario
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