GC-MS and Heavy Metal Analysis of Gasca D Herbal Formulation
Journal Title: Tropical Journal of Natural Product Research - Year 2019, Vol 2, Issue 8
Abstract
Received 14 July 2018 Revised 09 August 2018 Accepted 10 August 2018 Published online 10 August 2018 Gasca D herbal formulation is an antidiabetic medicine produced exclusively from natural ingredients. The aim of this study was to evaluate the levels of essential and toxic heavy metals as well as to identify bioactive compounds present in Gasca D herbal formulation. The level of some essential elements (Copper, chromium, Cobalt, Iron, Manganese, Nickel and zinc) and toxic (Cadmium, Arsenic, Vanadium, Mercury, and Lead) heavy metals were determined using microwave plasma-atomic emission spectrometry (MP-AES). The result shows no traces of Lead, Mercury, Arsenic and Zinc. Iron was found to have highest concentration 67.16 + 7.5 µg/g and Cadmium lowest concentration 0.4 + 0.03µg/g. Vanadium, the derivatives of which have been reported to have insulin-mimetic and antidiabetic properties was found at a concentration of 2.6 μg/g. The Gas Chromatography-Mass Spectrometric (GC-MS) analysis of Gasca D herbal formulation revealed the presence of 16 compounds which include N-Formyl-beta-alanine, Paromomycin, 3,4-Altrosan, Benzamide, 1,3,4-Thiadiazol-2-amine, Carbamodithioic acid, Carbonic acid, alpha-D-Glucopyranoside, Ethyl isocyanide, 2-Propanesulfinic acid, Propanamide, 2-Butenenitrile, Dicyclopropyl carbinol, Isoxazolidine, 1,5-Hexadiene, 10-Azido-1-decanethiol. The result indicates that the mean levels of toxic metals in Gasca D herbal formulation were below WHO permissible levels. Gasca D herbal formulation contains various bioactive compounds which may serve various medicinal applications.
Authors and Affiliations
Ibrahim S. Ismai, Ibrahim D. Gezawa, Muhammed F. Yahya, Imam A. Abdulkadir
Keywords
Related Articles
- EP ID EP494788
- DOI 10.26538/tjnpr/v2i8.5
- Views 109
- Downloads 0
Bombax costatum Pellegr. and Vuillet Stem Bark Extract Prevents Paracetamol and Carbon Tetrachloride-Induced Liver Injury in Rats
Received 26 March 2018 Revised 04 May 2018 Accepted 06 May 2018 Published online 10 May 2018 Bombax costatum is a commonly used medicinal plant in African traditional medicine in the treatment of liver disease. This stu...
Coconut (Cocos nucifera) and Moringa (Moringa oleifera) Oils Protect Against Cadmium-induced Toxicity in Albino Rats
Received 20 February 2018 Revised 26 March 2018 Accepted 02 April 2018 Published online 07 April 2018 Exposure to heavy metals is currently an increasing source of concern worldwide. The present study evaluated the effe...
Gastro-Floating Drug Delivery Systems - A Review
Sustained release and site targeted drug delivery system have been an interesting research topic in pharmaceutical sector to maximize therapeutic benefits and patient adherence to therapy. GastroFloating Drug Delivery Sy...
Antidepressant Effect of Methanol Stem Bark Extract of Adansonia digitata L. (Malvaceae) in Mice
Received 22 December 2017 Revised 24 January 2018 Accepted 30 January 2018 Published online 07 February 2018 Adansonia digitata (Malvaceae) is a plant native to Africa with all its parts used extensively since ancient t...
Evaluation of Analgesic and Anti-inflammatory Activities of Methanol Leaf Extract of Croton lobatus (Euphorbiaceae) in Rodents
Croton lobatus (Euphorbiaceae) is an annual herbaceous plant found throughout the West African region. The leaves of the plant are used in Senegal for treating whooping cough and to assuage the pain of scorpion sting in...