GC-MS TENTATIVE DETECTION AND CHARACTERIZATION OF HYDROXYTRAMADOL AS A METABOLITE OF TRAMADOL IN MAN
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2014, Vol 5, Issue 10
Abstract
The high concentrations of metabolites in the urine of tramadol abusers have made possible further investigation of the metabolism of this analgesic drug. In addition to the reported metabolites resulting from O- and N- demethylations, ring-hydroxylation has been detected in this work as a further route of tramadol metabolism. GC-MS and trimethylsilyl derivatization have provided the necessary data. Certain assumptions were necessary for corroborating the ring-hydroxylation route.
Authors and Affiliations
Babiker M El-Haj
Keywords
Related Articles
- EP ID EP152817
- DOI 10.7897/2230-8407.0510153
- Views 110
- Downloads 0
ANTIMICROBIAL SCREENING OF SOME NOVEL SUBSTITUTED CHALCONE DERIVATIVES
Chalcone is an aromatic ketone that forms the central core for the variety of important biological compounds, which are collectively known as chalcones. The derivatives of chalcones with an annular nitrogen atom in the p...
VALIDATION AND PROCESS DEVELOPMENT: A REVIEW
Total Quality Management and specifications according to regulatory guidelines involved in pharmaceutical production has a great impact significantly on the quality of the products. The validation protocol includes inven...
DIRECTLY OBSERVED TREATMENT SHORT-COURSE FOR TUBERCULOSIS: A THREE-YEAR SURVEY OF THE TREATMENT OUTCOME IN A TEACHING HOSPITAL IN NORTHEASTERN NIGERIA
The major challenges of treating patients with pulmonary tuberculosis have been those of compliance and increasing incidence of multi-drug resistance. The use of directly observed treatment-short course (DOTS) has been w...
PRESCRIBING PATTERN AND USE OF STEROIDS IN ASTHMA PATIENTS
Asthma affects people of all ages, India has an expected 15-20 million asthmatics according to world health organisation. Steroids are widely prescribed in asthmatic patients, forming a part of standard and most treatmen...
ANTI-DIABETIC POTENTIAL OF DELONIX REGIA
Gulmohar (Delonix regia) is well known for its nutritional and medicinal properties in all over world. This research was undertaken to test the effect of gulmohar leaves extract on the diabetes of Rat. Gulmohar leaves ex...