Gemcitabine and Carboplatin in Inoperable, Loco-Regionally Advanced and Metastatic Gallbladder Cancer- A Study from Northern Indian Cancer Institute
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2017, Vol 19, Issue 12
Abstract
Aims: The primary objective of this study was to determine the response rates of the gemcitabine and carboplatin combination chemotherapy in treatment naïve patients with inoperable gall bladder cancer. The secondary objectives were to evaluate the toxicity, progression free survival (PFS), and overall survival (OS). Methodology: Treatment naïve patients with histologically proven inoperable gall bladder cancer treated with gemcitabine and carboplatin chemotherapy between February 2011 and December 2014 were included in this study. The dose of gemcitabine was 1 gm/m2 on day 1 and 8, and carboplatin [target AUC (area under the concentration versus time curve in mg/ml) of 5] on day 1, in a 21 day cycle. CT scan was used for response assessment. Results: There were 32 men and 92 women with a median age of 59 years (range 26-75 years). Of the 124 patients, 9 (7.3%) patients achieved a complete response and 54 (43.5%) patients achieved a partial response for an overall response rate of 50.8%. The median PFS was 4.6 months [95% confidence interval (CI) 4–5.5 months], with 1-year survival rate of 20.2%. Common toxicity criteria (CTC) grade 3 anaemia was seen in 6 (4.8%) patients. Grade 3 and 4 neutropenia was observed in 11 (8.9%) and 4 (3.2%) patients respectively, whereas 9 (7.3%) patients experienced Grade 3 thrombocytopenia. Conclusion: The combination of gemcitabine and carboplatin is active in advanced gall bladder carcinoma with mild toxicity.
Authors and Affiliations
Vineet Talwar, Shubhra Raina, Varun Goel, Dinesh C. Doval
Keywords
Related Articles
- EP ID EP311398
- DOI 10.9734/BJMMR/2017/30843
- Views 98
- Downloads 0
Awareness and Utilization of Guidelines in the Management of Hypertension among Medical Practitioners in a Tertiary Hospital in Nigeria
Background: Hypertension is a public health problem in Sub-Saharan Africa, as it is responsible for increased cardiovascular morbidity and mortality. The need to improve the global control of high blood pressure and miti...
Is Childhood Ocular Trauma More Often in Families with Low Socio-economic Level?
Aim: To examine whether socioeconomic status as determined by the number of siblings, educational level, and monthly household income is associated with childhood eye injuries. Materials and Methods: Eighty six patients...
Bilateral Retrobulbar Optic Neuritis Caused by Varicella Zoster Virus in a Patient with AIDS
Aims: To report on a case of bilateral retrobulbar optic neuritis in a patient with acquired immune deficiency syndrome (AIDS) caused by varicella-zoster virus (VZV); and to review the literature focusing on: cases repor...
Awareness of the Oral Cancer Risk Factors in People from Nothern-Eastern Region of Poland
Background: The aim of the study presented in this paper is to investigate patient knowledge about the existence of oral cancer and the awareness of the impact of smoking on the development of this malignancy. Methods: P...
A Previously Uncharacterized Infectious-like Event Leading to Spatial Spread of Deaths Across England and Wales: Characteristics of the most Recent Event and a Time Series for Past Events
Aims: In 2003, 2008 and 2012, deaths in the UK showed unexpected and unexplained large increases similar in magnitude to the larger influenza epidemics seen before 2000. However there were no unusual levels of influenza...