Gender peculiarities of bone mineral density in patients with Parkinson’s disease
Journal Title: Біль. Суглоби. Хребет - Year 2018, Vol 8, Issue 1
Abstract
Background. Parkinson’s disease is a chronic progressive disease of the brain manifested by a combination of hypokinesia with rigidity, resting tremor and postural instability, as well as a wide spectrum of non-motor manifestations accompanied by an increased risk of osteoporotic fractures. The purpose of the study was to study the sexual characteristics of bone mineral density in patients with Parkinson’s disease. Materials and methods. Eighty nine patients with Parkinson’s disease and 89 patients of the corresponding age and sex without neurologic pathology were examined. Women and men of both groups did not differ in age, height and body weight. The bone mineral density (BMD) was determined by dual energy X-ray absorptiometry. Results. Osteoporosis in patients with Parkinson’s disease was registered significantly more often in women than in men (48 and 24.3 %, respectively) and significantly more often than in the control group. Significantly lower BMD was registered in patients with Parkinson’s disease compared with those of the control group: in men — at the level of the femoral neck, the distal forearm and the total body, in women — at the level of the lumbar spine, femoral neck and total hip, distal forearm and total body. The negative correlation of the BMD in different regions of the skeleton and age was recorded in women, in men this relationship was registered at the level of the distal forearm. The positive correlation was found between the BMD and body mass index in men and women. Conclusions. The results of our study suggest that Parkinson’s disease leads to the development of osteoporosis, but the condition of bone tissue in patients with Parkinson’s disease has gender features, in particular, the BMD in women is more dependent on age, and in men — on body mass index.
Authors and Affiliations
V. V. Povoroznyuk, M. A. Bystrytska, I. M. Karaban, N. V. Karasevich
Keywords
Related Articles
- EP ID EP299802
- DOI 10.22141/2224-1507.8.1.2018.130695
- Views 82
- Downloads 0
Multidirectional vector pathways of vitamin D metabolism as modifiers of its interaction with drugs
Background. The comorbid pathology characteristic of the elderly and senile people may lead to polypharmacy. The leading role in the metabolism of drugs is played by the cytochrome (CY) P450 system. The use of vitamin D...
Vitamin D and Iodine Deficiency:Impact on Health and Aging
The article is a review of the key highlights of the conference on Vitamin D and Iodine Deficiency, which took place on 21–22 of April in Chernivtsy (Ukraine). Data about status of Vitamin D in Ukrainian population, impa...
Giant cell arteritis: epidemiology, diagnosis, prognosis
Giant cell arteritis (GCA) is the most common systemic vasculitis affecting large vessels in subjects over 50 years old. This disease is associated with an increased risk of other inflammatory diseases and vascular con...
Features of Constitution in Women of Various Ages
.
Osteochondrosis: Pathogenetic Bioregulatory Limitations of Using the Drug Discus Compositum
Treatment of osteochondrosis is one of the actual problems in the therapy of degenerative-dystrophic diseases of the musculoskeletal system [1]. The clinical studies have shown that osteochondrosis — a disease of the who...