Genes Controlling 2-deoxyglucose Induced Lysis and Formation of Reactive Oxygen Species in Schizosaccharomyces pombe
Journal Title: Polish Journal of Microbiology - Year 2017, Vol 66, Issue 3
Abstract
Schizosaccharomyces pombe cells of strains each carrying a deletion of one of the genes snf5, ypa1, pho7 and pas1 and of a strain overexpressing gene odr1, have been previously shown to grow in presence of the toxic glucose analogue 2-deoxyglucose (2-DG). Here we report that these genes control 2-DG induced lysis and are, with the exception of odr1, also involved in control of formation of reactive oxygen species (ROS) upon exposure of cells to H2O2. Lysis of deletion strains, but not of strain overexpressing odr1, is dependent on glucose concentration of the medium whereas ROS formation is glucose independent.
Authors and Affiliations
Akshay Vishwanatha, Cletus J. M. D’Souza, Martin E. Schweingruber
Keywords
Related Articles
- EP ID EP223706
- DOI 10.5604/01.3001.0010.4877
- Views 68
- Downloads 0
MEMORIAL TRIBUTE To Professor Władysław J.H. Kunicki-Goldfinger (1916–1995)
We, his senior students at the University of Warsaw, wish to remember our Teacher and Master of so many years who devoted his exemplary life to fighting for good science and for justice. He is an icon for us to follow.
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