GENETIC POLYMORPHISMS ASSOCIATED WITH CHLOROQUINE RESISTANCE AMONG PLASMODIUM FALCIPARUM ISOLATES FROM ALJUNAYNAH DISTRICT, WEST DARFUR STATE, SUDAN
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2018, Vol 4, Issue 12
Abstract
Chloroquine CQ resistance has been shown to be associated with point mutations in Pfcrt and Pfmdr1. These genes encode for digestive vacuole transmembrane proteins Pfcrt and Pgh1 respectively. Polymorphisms were examined in these genes in25 isolates from Aljunaynah, west Darfur state, Sudan. The isolates were subjected to PCR-RFLP analysis for the Pfmdr1 N86Y and Pfcrt K76T mutations. The frequency of mutant allele for CQ pfcrt T 76 was19 (38%) and pfmdr1 Y 86 was 7 (14%). The study concluded that the frequency of chloroquine drug resistance molecular markers were higher in the study area and lower than that reported in other Sudan states. The result necessitates the evaluation of CQ in vivo therapeutic efficacy in endemic areas for more effective malaria control strategies.
Authors and Affiliations
Abdalmoneim M. Magboul
Keywords
Related Articles
- EP ID EP666049
- DOI -
- Views 210
- Downloads 0
MEDICINAL USES OF AMRITA [HYDNOCARPUS LAURIFOLIA (WILLD.) MIERS]
Guduchi (Tinospora cordifolia) is a popular medicinal plant spread across the tropics. Its effectiveness in therapy is well known globally. Lesser known are its dietary benefits. Guduchi is being used in Diet by various...
STUDY OF MANAS PRAKRITI WITH SPECIAL REFERENCE TO RAJAS AND TAMAS AND EFFECT OF MEDITATION ON IT
Ayurveda is a science of life. Ayurveda says that the living being in a combination of Sharir, Indriya, Atma and Manas. Diseases are defined as those which on conjuction cause pain. They are located in Mind and body. Raj...
HARIDRA (CURCUMA LONGA LINN.): AN AYURVEDIC REVIEW
Turmeric is a ayurvedic medicine which is a member of the ginger family (Zingiberaceae). Rhizomes are horizontal underground stems that send out shoots as well as roots. The bright yellow color of turmeric comes mainly f...
CLINICAL PROFILE AND OUTCOMES OF PARAPHENYLENE DIAMINE (KALA PATHAR) POISONING AT A TERTIARY CARE CENTER, PAKISTAN
Aim of study: The objective of this study was to explore the clinical course and outcome of patients with this poisoning. Methodology: It is a cross-sectional observational study conducted at Nishtar Hospital, Multan for...
A COMPARATIVE STUDY OF SAFETY AND EFFICACY OF BETAMETHASONE ORAL MINI PULSE (BOMP) AND WEEKLY AZATHIOPRINE PULSE (WAP) IN THE TREATMENT OF ALOPECIA AREATA
Alopecia areata is an autoimmune disease, characterized by non-scarring hair loss on the scalp or any hair bearing surface.[1] Alopecia areata is common disease.[2] The lifetime risk of developing this condition is repor...