ГЕНЕТИЧНА СТРАТИФІКАЦІЯ СЕРЦЕВО-СУДИННОГО РИЗИКУ В ПАЦІЄНТІВ З АРТЕРІАЛЬНОЮ ГІПЕРТЕНЗІЄЮ НА ОСНОВІ ОЦІНКИ ПОЛІМОРФІЗМІВ ГЕНІВ-КАНДИДАТІВ
Journal Title: INTERNATIONAL ACADEMY JOURNAL "Web of Scholar" - Year 2018, Vol 2, Issue 2
Abstract
240 patients with arterial hypertension (AH) were examined and stratificated depend from prognostic cardiovascular risk according to the traditional criteria (ESC 2013). The patients were divided into 4 groups: with low, moderate, high or very high cardiovascular risk. Then the analysis of polymorphisms of the following candidate genes (ADD1:1378, AGT:704, AGT: 521, AGTR1:1166, AGTR2: 1675,CYP11B2:-344, GNB3:825, NOS3:-786, NOS3:894) was performed by PCR and gene modification index was formed, which is based on total evaluation of pathological genotypes. Gene modification index from 0 to 20 % was considered as low genetic risk, from 21 to 40 % - moderate risk, from 41 to 70 % - high risk, from 71 to 100 % - very high risk. The statistical analysis of correlations was made between the traditional and genetic stratification scores. Analyzing obtained data of research, it is shown that proposed genetic risk stratification score has a significantly high correlation with traditional stratification score of cardiovascular risk and can be used with prognostic purpose in patients with AH. Additionally, genetic stratification risk score can have obvious benefits for the purposes of primary prevention of arterial hypertension.
Authors and Affiliations
Вадим Миколайович Бондар, Катерина Сергіївна Чернишова
Keywords
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