Gestational Trophoplastic Disease in Babylon Maternity and Paediatrics Teaching Hospital a Prospective Study
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 7
Abstract
Background: Gestational trophoblastic tumours arise from the cells of conception and form a range of related conditions, from the benign partial mole to the aggressive malignancies of choriocarcinoma and placental site tumours. Despite the rarity of them, patients with molar pregnancies requiring additional treatment after evacuation can expect cure rate 100%. Objectives: In the present study, we evaluated six years period of trophoblastic diseases in women attending Babylon Maternity and Paediatrics Teaching Hospital in prospective study. Patients & Method: This study was a descriptive observational study, conducted from January 2008 until January 2014 in Babylon Maternity and Paediatrics Teaching Hospital, all cases with molar pregnancy been involved, after diagnosis been treated and followed up. Those with persistent high hCG referred for chemotherapy. Results: Our study involved 83 patients with trophoblastic disease.The overall mean age was (28.40±8.89) years old and (24.1%) of patients were older than 35 years. In our study 83 patients with trophoblastic disease 74 of them were having complete hydatidiform mole (89.2%), four patients (4.8%) having partial mole, four patients with invasive mole (4.8%) and one patient with choriocarcinoma (1.2%).Regarding parity ranged from (0 – 8)para, 28 patients (33.8%) their parity were less than three, meanwhile 55 patients (66.3%) their parity more than three.About patient’s residence in our study 56 patients (67.5%) were from rural area, meanwhile, 27 patients (32.5%) were from urban area.In this study, 83 women with trophoblastic disease six of them ended by hysterectomy(7.2%), 74 women with complete hydatidiform mole suction curettage performed for them only one patient ended with hysterectomy. Regarding chemotherapy 16 patients (19.3%) out of 83 received chemotherapy eleven after complete hydatidiform mole for persistent high hCG forming (8.14%), four patients with invasive mole and one case choriocarcinoma, while 67 patients (80.7%) www.jmscr.igmpublication.org Impact Factor 1.1147 ISSN (e)-2347-176x Dr.Bushra J. Al- Rubaiey JMSCR Volume 2 Issue 7 July 2014 Page 1652 JMSCR Volume||2||Issue||7||Page 1651-1662||July 2014 2014 did not received any chemotherapy.Regarding serum B-hCG levels pre-evacuation in our study for complete hydatidiform mole mean (29540+-26151) mIU/ml, for partial mole more than 20000mIU/ml, for invasive mole more than 30000 mIU/ml and for choriocarcinoma more than 100000 mIU/ml. Conclusion: Trophoblastic diseases occur during the fertility age mostly, and there is an increased risk with extreme of age and more previous pregnancies;Hydatidiform mole was thecommonest type of trophoblastic disease in these patients.(19.3%) of the patients necessity to chemotherapy.
Authors and Affiliations
Dr. Bushra J. Al- Rubaiey
Keywords
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