Glycoconjugates In Cancer
Journal Title: UNKNOWN - Year 2016, Vol 2, Issue 1
Abstract
Basing our diet on carbohydrates is determined by many research tasks. Carbonhydrate groups are present as structural and protective components in connective tissue of animal organisms and in addition they are involved in plant and bacteria cell wall as structural elements. They form glucoconjugates showing different characteristics on cell surface by covalent binding to lipids and proteins. These formations play a major role in such important events; intercellular recognition, cell-cell interactions and the interactions with the environment, cellular development and growth, cellular adhesion and regeneration. Carbohydrates spend 50% of the glycosylation of proteins in mammalian cells and take over some tasks of different proteins in the cell. Glycobiology the study of the vital importance of carbohydrate groups and their functions is investigating their role in the production of organisms. Glycobiology studies have determined the molecular structure of the sugar in glycoconjugates, the control of glycosylation patterns and the amount and copying carried out in the field of enzyme genes associated with phenotypic determinations. New strategies and techniques that study the structures and functions of carbohydrates are making strides toward creating more effective drugs with glycoproteins. Changes in the structure of glycoproteins and other glycoconjugates on the surface of cancer cells in cancer metastasis is thought to be important. Cancer cells in studies with the cell surface in the transformation of normal cells to cancer cells was found to have significant changes in the glycoconjugate. A tumour of the cellular defence system, by the use of certain substances capable of binding to this region, which undergoes changes in the surface of the cancer cells, may be more easily eliminated through quicker and better recognition. Protein-bound carbohydrates increase in tumour specimens of patients. Increases in the carbohydrate content of the normal protein, the glycoprotein of the tumour cells and production of new liver tissue or lymphoreticular tissues may be due to increased synthesis of glycoprotein. In this review, the structure of glycoconjugates and the glycobiologic approach in anti-cancer drug development and changes of cell surface components in cancer tissues were examined.
Authors and Affiliations
Martin Orlinov Kanev, Elvan Bakar
Keywords
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