Gold nanoparticles from magnetite for the detection of amyloid proteins in neurodegenerative diseases
Journal Title: One Health & Risk Management - Year 2022, Vol 3, Issue 1
Abstract
Introduction. Currently, neurodegenerative diseases (ND) are the fourth leading cause of death worldwide that pose a great challenge in the development of tools for early diagnosis. Thus, advances in science seek sensitive and selective detection systems and this manuscript will highlight the importance of nanotechnology. Material and methods. A literature review was conducted on the representative findings of NPs technologies in neurodegenerative diseases. Articles written in both English and Spanish were included. References between 2015-2021 were also taken into account. Results. One of the most representative techniques, AuNP was specifically implemented, together with a magnetic center composed of magnetite, which has as a specific ligand with a C-terminal cysteine domain present in the B-amyloid protein, which adhere directly to the surface of the NPs, characterizing the anomalous protein. Subsequently, by means of nanosensors capable of detecting and measuring different concentrations, these pathologies are identified at an early stage. Conclusions. Today, along with the advent of biotechnology, it has been possible to design techniques with NPs that allow the identification of specific mutations and provide diagnosis in individuals. In the investigative models of AuNP, it is possible to infer that the capabilities that make them representative focus on their magnetism and biofunctionality, by specifically binding to amyloid peptides and other ligands present in the protein, which are the major components of amyloid plaques used in these studies.
Authors and Affiliations
Alejandro ORTIZ, Zeyris HERRERA, Johanna MOSCOSO
Keywords
Related Articles
- EP ID EP698659
- DOI 10.38045/ohrm.2022.1.02
- Views 120
- Downloads 0
Concerns regarding the effects of the COVID19 pandemic on children health
Introduction. The unexpected situations (lockdown, online school, social distancing) introduced from March 2020 to stop the spread of COVID-19 in most countries worldwide, have affected every citizen. Currently, after mo...
First national point prevalence survey of healthcare-associated infections and antimicrobial use in acute care hospitals in the Republic of Moldova
Introduction. HAIs present a major public health problem with an impact on morbidity, mortality and quality of life. The objective of the study was to highlight the problem of HAIs and AM use, identification of risk fact...
Epidemiological aspects in trophic ulcers with methicillin-resistant Staphylococcus
Introduction. Trophic ulcer continues to be a major clinical problem, currently having a significant socio-economic impact. The association of microbial infections, especially with antibiotic-resistant bacteria, is one o...
Epidemiological situation regarding the new type of coronavirus infection (COVID-19) among healthcare workers in the Republic of Moldova
Introduction. The emergence of the new coronavirus (SARS-CoV-2) has led to a rapid spread of novel infection (COVID-19) worldwide. Since February 1, 2021, to date, more than 103,989,900 cases and more than 2 million deat...
Life science professional responsibility in an age of dual-use research
Biotechnology is progressing at an unprecedented pace promising to bring tremendous benefits by responding to health, socio-economic, and environmental challenges. At the same time, cutting-edge life science advances rai...