HAEMATOLOGICAL CHANGES IN NEONATAL SEPSIS- A STUDY IN A TERTIARY CARE HOSPITAL
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2018, Vol 5, Issue 33
Abstract
BACKGROUND Sepsis is the commonest cause of neonatal mortality. Early recognition of neonatal sepsis is difficult as the clinical signs and symptoms are non-specific and the failure or delay in treatment may result in significant mortality and morbidity. MATERIALS AND METHODS Blood samples were taken from neonates attending Regional Institute of Medical Sciences, Imphal, Manipur, India with clinical features of sepsis. Various haematological tests were performed including haemoglobin level, total WBC count, total PMN count, immature PMN count, I:T PMN ratio, I:M PMN ratio, degenerative changes in PMN and platelet count. Haematological scoring and blood culture were done for each case. Correlation of the various haematological parameters was done with the blood culture. RESULTS A total of 101 neonates with clinical features of neonatal sepsis were included in the study. Out of all the cases, 59 (58.4%) cases were ≤7 days of age. Early onset sepsis was present in 58.4% of cases and late onset sepsis was present in 41.6% of the cases. Bacterial culture was positive in 27 (26.7%) cases. Among the organisms grown, coagulase negative staphylococci (CoNS) was the most common organism accounting to about 55.6%. Abnormal total PMN count had the highest sensitivity of 96.2% but the lowest specificity of 28.4%, among all the individual parameters. 47 cases had a haematological score ≤2, 38 cases had a score of 3-4 and 16 cases had a score ≥5. The sensitivity, specificity, positive predictive value and negative predictive values of the tests increased as the score increased. Also, the specificity of the two-test combination was either similar to or higher than the individual test at the cost of sensitivity. CONCLUSION None of the haematological parameters studied can be used alone for a reliable diagnosis of neonatal sepsis. However, a combination of tests and a haematological scoring system is a very useful diagnostic aid to the clinicians.
Authors and Affiliations
Phuritshabam Pinky, Rajesh Singh Laishram, Khagokam Ambala Devi, Jesu Pandian R. , Tamphasana Devi R. K.
Keywords
Related Articles
- EP ID EP570995
- DOI 10.18410/jebmh/2018/498
- Views 113
- Downloads 0
INCIDENCE AND PREDICTORS OF DIFFICULT LARYNGOSCOPY IN PATIENTS UNDERGOING CORONARY ARTERY BYPASS GRAFTING
BACKGROUND Patients presenting for coronary artery bypass graft surgery can have higher incidence of difficult airway. Awareness about the incidence and predictors of difficult airway in CABG patients will help the anaes...
ADULT ONSET STILL’S DISEASE-A DIAGNOSIS OF EXCLUSION
PRESENTATION OF CASE A 27-year-old lady, married came with chief complaints of fever since 1-month duration and pain in both knee joints, since 20 days. Fever was high grade, 2-3 spikes /day, not associated with chills o...
COMPARISON OF IMPROVEMENT IN CLINICAL, SPIROMETRIC AND OXYGENATION PARAMETERS AFTER NEBULISATION WITH LEVOSALBUTAMOL AND FORMOTEROLBUDESONIDE IN MODERATE TO SEVERE ASTHMA
BACKGROUND Asthma is characterized by recurrent attacks of breathlessness and wheezing, which vary in severity and frequency from person to person, 1 because asthma is a clinical syndrome, there is no gold standard for i...
CLINICAL STUDY OF ASSOCIATION OF BMI WITH NEPHROPATHY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
BACKGROUND Diabetes is a common disease that is associated with high mortality and morbidity from macro vascular and micro vascular complications. Whereas macro-vascular complications, particularly cardiovascular disease...
COMPARISON STUDY OF COUGH SUPPRESSION DURING FLEXIBLE BRONCHOSCOPY USING LOCAL ANAESTHESIA IN DIFFERENT TECHNIQUES- (10% LIGNOCAINE SPRAY + 2% LIGNOCAINE AS YOU GO) VERSUS (4% LIGNOCAINE NEBULISATION + 2% LIGNOCAINE AS YOU GO)
BACKGROUND Anaesthesia for bronchoscopy poses unique challenges for the pulmonologist. By definition, bronchoscopy is an endoscopic technique to visualise the inside of the airways, it is a pivotal diagnostic and therape...