Haemoassessment of Dogs Experimentally Infected with Single and Conjunct Trypanosoma congolense and Ancylostoma caninum and Treatment with Diminazene Aceturate and Mebendazole
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 14, Issue 3
Abstract
The haemoassessment of dogs with single Trypanosoma congolense (T. congolense) and conjunct T. congolense /A. caninum was determined in this study. Twelve mongrels of both sexes weighing between 4 to 8 kg were grouped into 3 of 4 members each. The group i (GPI) was the uninfected (control), group ii (GPII) was infected with T. congolense and group iii (GPIII) was conjunct infection of T. congolense/A. caninum. Post acclimatization GPIII was infected with 200 infective L3 of A. caninum, 2 weeks later both GPII and GPIII were given 2.5x106 trypanosomes intraperitoneally. Three weeks post trypanosome infection, treatment was done with 100 mg of mebendazole twice daily for 3 days and 7 mg/kg of diminazene aceturate. Result showed a significant decrease (p<0.05) in PCV, Hb and Rbc of both GPII and GPIII. The decrease in GPIII was more compared to that in GPII. There was significant decrease (p<0.05) in neutrophil, monocyte, lymphocyte and eosinophil counts of both GPII and GPIII except in basophil count which showed no significant difference (p<0.05) from GPI (control) throughout the experiment. Treatment with both diminazene aceturate and mebendazole cause significant haematological improvement.
Authors and Affiliations
R. I. O. Nwoha, B. M. Anene
Keywords
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- EP ID EP340113
- DOI 10.9734/BJMMR/2016/24067
- Views 73
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