Haemodynamic effects of low dose Dexmedetomidine infusion in patients undergoing laparoscopic cholecystectomy –A randomized study
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2016, Vol 4, Issue 5
Abstract
Laparoscopic surgery had several advantages over conventional surgery for the patient. Dexmedetomidine due to its distinct properties can be used as an anaesthetic adjuvant in the form of intravenous infusion. We studied the use of low dose dexmedetomidine infusion in laparoscopic surgery and its effect on hemodynamics, sedation scores and analgesic requirements. After the approval of the hospital ethics committee of Mahatma Gandhi Memorial Hospital Warangal, Telangana state 90 patients, aged 25 to 52 years, ASA grade I to II, and scheduled for laparoscopic cholecystectomy, were included in the study. Control Group C received normal saline0.9%, Group D1received dexmedetomidine 0.2 μg/kg/h and Group D2 received dexmedetomidine 0.4μg/kg/ h intravenously. There was no significant difference in preoperative hemodynamic parameters between the groups. In control Group significant haemodynamic stress response was seen following laryngoscopy, tracheal intubation, creation of pneumoperitoneum and extubation. Index medetomidine groups, the haemodynamic response were significantly attenuated. In addition, dexmedetomidine provides lighter sedation and reduces the post‑operative analgesic requirements without any significant adverse effects. Dexmedetomidine 0.4mcg/kg/h was significantly more effective than 0.2mcg/kg/h and control group. Keywords: Laparoscopy, Cholecystectomy, Dexmedetomidine, Haemodynamic response, Analgesia.
Authors and Affiliations
Laxmi Narsaiah G, Murali. CH, Srinivasa Rao. B, Praveen Kumar. D, Sravan Kumar. G
Keywords
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