harmacokinetics and bioavailability of difloxacin in camel
Journal Title: Journal of Veterinary Medical Research - Year 2005, Vol 15, Issue 2
Abstract
The pharmacokinetic profile of difloxacin was investigated in camels after single intravenous and intramuscular administration of 5 mg kg-1 b.wt. After i. v. injection, serum concentration time curve was best described as two compartment open model. The distribution and elimination half lives (t0.5 (') and t0.5())) were 0.513± 0.01 h and 6.3±0.15 h. respectively. Difloxacin was distributed extravascularly with a volume of distribution (Vdss) 1.10 ± 0.035 l kg-1., and total body clearance (CLB) of 0.141+ 0.031 l kg-1 h-1. following intramusclar injection, peak serum concentration (Cmax) 2.59 ± 0.19 ug ml-1 attained after Tmax 3.05 ± 0.035 h. The absorption and elimination half lives (t0.5 (ab) and t0.5 (el)) were 0.95 ± 0.003 and 5.86 ± 0.33 h., respectively. The systemic bioavailablility (F) and the plasma protein binding were 87.95 and 23 %, respectively.
Authors and Affiliations
M. A. Tohamy1; A. A. M. El- Gendy1; M. Ismail2 1Pharmacology Department, Faculty of Veterinary Medicine Beni-suef University, Beni-suef, Egypt 2Pharmacology Department, Faculty of Veterinary Medicine, Cairo University, Cairo, Egypt
Keywords
Related Articles
- EP ID EP682716
- DOI -
- Views 246
- Downloads 0
Multiplex PCR for simultaneous detection of 3 major fish pathogens incriminated in bacterial septicemic syndrome
Fish with bacterial septicemic syndrome (BSS) exhibit very similar clinical signs regardless of the etiological agents. Members of Aeromonas, Pseudomonas, Vibrio, Edwardsiella, Streptococcus and Lactococcus species are c...
Epizootiology of lumpy skin disease outbreak in cattle in middle of Egypt, 2006
The current investigation studied an outbreak of lumpy skin disease of cattle in Beni-Suef and Al-Fayium governorates from March up to September 2006. Epidemiological data over a total of 5500 cattle from all ages, breed...
Bovine Parapoxvirus: Isolation and pathogenicity studies
A disease characterized by papules, nodules, vesicles, pustules and ulcers on teats and udder as well as drastic drop in milk production was seen among a cattle farm in Fayoum Governorate, Egypt. A virus was isolated by...
Ultrasonography of the mammary gland in ruminants
Information regarding the use of ultrasonography in the diagnosis of udder and teat affections is scarce in ruminant. The present study was conducted on 30 cows, 20 ewes and 45 does. The surgical affections of udder and...
EFFECT OF SOME PLANT OILS ON REPRODUCTIVE ACTIVITIES IN FEMALE ALBINO RATS
The present study aimed to determine the effect of adding plant oils; extra virgin olive oil (EVOO), sunflower and soybean to animal feed on serum estradiol (E2) and progesterone (P4) levels, histological structure of ov...