Hematological Profile in Patients Suffering From Tuberculosis and Treatment Response
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 10
Abstract
Background: Reversible peripheral blood abnormalities are commonly associated with pulmonary tuberculosis and these hematological changes act as marker for the diagnosis, prognosis and response to therapy. There is no comprehensive study assessing the haematological abnormalities in these patients from the Indian subcontinent. The present study has been an attempt to investigate hematological changes in patients with active pulmonary and extrapulmonary TB. An attempt has also been made to assess the effect of six months antituberculosis therapy on the haematologic abnormalities. Material & Methods: The study subjects included 100 patients above 12 years of age without HIV coinfection of newly diagnosed cases of pulmonary and extrapulmonary tuberculosis diagnosed. For haematological analysis, about 3-4 ml peripheral venous blood was drawn aseptically with the help of sterile syringe. Two ml was transferred into a tube containing 0.2 ml of 4% EDTA solution and analyzed in the Hematology Analyzer for evaluation of different blood parameters. The remaining 2 ml of the blood were used for ESR determination. Results: Out of the 100 cases of tuberculosis collected from our hospital, 55 patients were PTB, and 45 were of extra-pulmonary tuberculosis. Anemia was identified in 71 patients (71%) at the time of diagnosis of TB. In 38 patients, the hemoglobin concentration was less than 10 g/dL. Mean ESR in all patients was 67.6 mm/hr with no statistically significant difference between pulmonary, extra-pulmonary and disseminated TB. The WBC count presented variable features. Total leukocytes count was lower than normal in 5 (7.8%) and 3 (8.8%), while lymphocytopenia in 37 (57.8%) and 14 (41.2%) in male and female patients respectively. Thrombocytopenia were observed in 9 (14%) and 4 (11.8%) in male and female patients respectively. Discussion: Some haematological abnormalities are quite common in patients with pulmonary TB and physicians must maintain a high index of suspicion for diagnosis of pulmonary TB in patients with these abnormalities.
Authors and Affiliations
Saket Kumar Mandal
Keywords
Related Articles
- EP ID EP214585
- DOI -
- Views 78
- Downloads 0
Effects of Addition of Clonidine to Bupivacaine in Spinal Anaesthesia for Abdominal Hysterectomy
Hyperbaric bupivacaine is a commonly used local anaesthetic for subarachnoid blocks. Several additives are added to prolong the action of intrathecal bupivacaine. We evaluated the effects of addition of 60μgms clonidine...
Adhesive Capsulitis in Diabetic Patient Treated with Manual Therapy and Closed Kinematic Exercise – An Evidence Based Study
Introduction: Prolonged posture related soft tissue pain are common among desk work nature of job. Pain and reduction in use of arm can give rise to diminished daily activities and quality of life aims and objectives of...
Comparison of Brain Magnetic Reasoning Imaging (MRI) Image Information between T1 Turbo Inversion Recovery (TIR) With T2 Fluid Attenuated Inversion Recovery (Flair) in Case of Epilepsy
Background: Examination MRI of brain coronal oblique slices in cases of epilepsy is usually performed using T1 turbo inversion recovery (TIR) or T2 fluid attenuated inversion recovery (FLAIR) sequences. Objective: The pu...
Zygomycosis and Aspergillosis of Rhinomaxillary Region
Fungal infections has gained a remarkable interest in the past few decades, owing to increase in immunocompromised conditions among the population.A variety of organisms are responsible for paranasal mycosis, Aspergillus...
Surveillance of drug sensitivity of bacteria in skin ulcer infections
Purpose: The bacterial manifestation in Skin ulcer is a common type of disease affecting patients' health and quality of life. Due to increases in antibiotic resistance, the difficulty of its management. Methods: A prosp...