Hemoglobin profiles of siblings of thalassemia patients
Journal Title: Paediatrica Indonesiana - Year 2015, Vol 55, Issue 2
Abstract
Background Thalassemia and hemoglobinopathies are themost common inherited disorders in many areas of the world,including South East Asia. The siblings of thalassemia major is agroup of high risk to carry the gene of thalassemia. Determiningthe carrier is useful for early treatment planning and preventionto the next child.Objective To determine carrier status among siblings ofthalassemia patients using a capillary electrophoresis system.Methods A cross-sectional study on the siblings of thalassemiamajor patients was performed from January 2011 to February2012 at Dr. Moewardi Hospital. Complete blood counts wereperformed in the siblings. Subjects with mean corpuscular volume(MCV) <80 fl and mean corpuscular hemoglobin (MCH) <27pg were subjected to analize hemoglobin fraction by capillaryelectrophoresis.Results Of the 26 subjects, there were 12 males and 14 females.The mean age was 9.38 (SD 6.8) years (range 1 to 29 years). Fromthe siblings, 10 were identified as normal, 5 were identified as ßthalassemia carriers and 5 were hemoglobin E (HbE) carriers. Sixsiblings were diagnosed with ß thalassemia/ HbE.Conclusion There are high occurrence of the two common typesof thalassemia carriers (ß and HbE) in our small group of subjectswho had a family history of thalassemia. Most of the siblingsof thalassemia had low MCV and MCH.
Authors and Affiliations
Muhammad Riza, Septin Widiretnani
Keywords
Related Articles
- EP ID EP448526
- DOI 10.14238/pi55.2.2015.70-3
- Views 78
- Downloads 0
Correlation between lipid profile and C-reactive protein in children with nephrotic syndrome
Background Nephrotic syndrome (NS) causes dyslipidemia in children, which can be long term or intermittent. Dyslipidemia has long been established as a risk factor for atherosclerosis. An early sign of atherosclerosis is...
Anti-S. typhi Vi IgG levels in children with and without typhoid vaccinations
Background Typhoid fever is endemic to Indonesia, with an annual incidence of 13/10,000 people. Vaccination has been shown to be an effective method to prevent typhoid fever. Of several vaccine types, the polysaccharide...
Depression in children with thalassemia major: prevalence and contributing factors
Background Thalassemia major is a chronic disease requiring lifetime treatment. A recent study showed that 11-62% of thalassemia patients developed depression, which is associated with high morbidity and mortality. Under...
Domperidone and maternal milk volume in mothers of premature newborns
Background Mothers of premature newborns often have difficulty giving adequate breast milk volume to their infants. Domperidone is an antagonist of peripheral dopamine receptors and believed to increase breast milk produ...
Natural resistance-associated macrophage protein 1 gene polymorphisms in thalassemia patients with tuberculosis infection
that needs regular blood transfusions leading to accumulation of iron in the cells. This iron overload level in macrophage might cause intracellular bacteria, particularly Mycobacterium tuberculosis (MTB) to multiply. Po...