Hemoglobin profiles of siblings of thalassemia patients
Journal Title: Paediatrica Indonesiana - Year 2015, Vol 55, Issue 2
Abstract
Background Thalassemia and hemoglobinopathies are themost common inherited disorders in many areas of the world,including South East Asia. The siblings of thalassemia major is agroup of high risk to carry the gene of thalassemia. Determiningthe carrier is useful for early treatment planning and preventionto the next child.Objective To determine carrier status among siblings ofthalassemia patients using a capillary electrophoresis system.Methods A cross-sectional study on the siblings of thalassemiamajor patients was performed from January 2011 to February2012 at Dr. Moewardi Hospital. Complete blood counts wereperformed in the siblings. Subjects with mean corpuscular volume(MCV) <80 fl and mean corpuscular hemoglobin (MCH) <27pg were subjected to analize hemoglobin fraction by capillaryelectrophoresis.Results Of the 26 subjects, there were 12 males and 14 females.The mean age was 9.38 (SD 6.8) years (range 1 to 29 years). Fromthe siblings, 10 were identified as normal, 5 were identified as ßthalassemia carriers and 5 were hemoglobin E (HbE) carriers. Sixsiblings were diagnosed with ß thalassemia/ HbE.Conclusion There are high occurrence of the two common typesof thalassemia carriers (ß and HbE) in our small group of subjectswho had a family history of thalassemia. Most of the siblingsof thalassemia had low MCV and MCH.
Authors and Affiliations
Muhammad Riza, Septin Widiretnani
Correlation of heart failure severity and N-terminal pro-brain natriuretic peptide level in children
Background Heart failure affects morbidity and mortality in children with heart disease. There is no single, specific test to diagnose heart failure. The modified Ross Reithmann scoring system has been used to classify...
Risk factors of stunting in children aged 24-59 months
Abstract Background Childhood stunting (low height-for-age) still remains a global health problem because it increases the risk of disturbances in growth and development as well as mortality. The prevalence of stunting...
A comparison of axillary and tympanic membrane to rectal temperatures in children
Background Core body temperature measurement is not commonly done in pediatric populations because it is invasive and difficult to perform. Therefore, axillary and tympanic membrane temperature measurements are preferabl...
Soy-based infant nutrition: a review
Dietary consumption of soy varies worldwide.In Asia, people traditionally consume largequantities of soy, while in Europe, soy is notpart of the traditional or daily eating habits.The USA is a major soy producer. The mea...
Risk factors and the occurrence of cerebral palsy in high risk infants
Background The incidence of cerebral palsy (CP) has increased due to better survival rates of high-risk babies. Early detection and time to the occurrence of CP in the first year of life is important in order to provide...