Hepatitis B Vaccination in Chronic Kidney Disease:- Experience in A Tertiary Care Centre
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 3
Abstract
Background: The study was conducted to examine the seroconversion rate for hepatitis B vaccination in Chronic Kidney Disease (CKD) patients and the factors which influence the sero conversion rate . Methodology: This is a descriptive study which included 235 patients with CKD (chronic kidney disease) with eGFR < 60ml/min/m2 and they were given 40microgm of Hepatits B vaccine intramuscularly over deltoid at 0,1,2,6 months . Patient characteristics were recorded.Patient response was assessed by measuring antibodies to hepatitis b surface antigen (AntiHBs Ab) six weeks after receiving the 4th dose. Results : 83% of the patients were seroconverted with titre ≥ 10IU/L .The eGFR and and age are found to influence the titre. Aetiology of CKD and gender has no effect on the sero conversion status. Conclusion: HBV vaccination should be started to CKD patients at the earliest preferably in the first visit itselfas the seroconversion rate declines with progression of CKD.
Authors and Affiliations
Dr Gomathy S, Dr Usha Samuel, Dr Arun K A, Dr Pradeep B
Keywords
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