HEPATOPROTECTIVE ACTIVITY OF SEABUCKTHORN FRUIT POWDER (HIPPOPHAE RHAMNOIDES) IN CARBONTETRACHLORIDE CHALLENGED RAT MODEL
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 4
Abstract
Seabuckthorn (Hippophae rhamnoides) aqueous and alcoholic extract of fruit powder at dose levels 400 mg/kg body weight administered orally for seven days to the ccl4 challenged rats produced significant reversal of biochemical changes in liver and serum intoxicated by ccl4 treatment. The aqueous and alcoholic extracts prevented wide range of tissue injury in ccl4 challenged rats as evidenced by significant reduction in GOT, GPT, ALP, Total Bilurubin and LPO levels. The aqueous and alcoholic extracts treated animals produced significant increase in the levels of Total Protein, GPX, GST, GRD, SOD and Catalase in animals challenged with ccl4.
Authors and Affiliations
P. Shashikanth , G. Sandeep , K. Karunakar , Venkateshwar Rao
Keywords
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