Hepatoprotective activity of Somanathi Tamra Bhasma in paracetamol induced liver toxicity in albino- rats
Journal Title: The Journal of Phytopharmacology - Year 2015, Vol 4, Issue 3
Abstract
To Investigate the hepatoprotective activity of Somanathi Tamra Bhasma against paracetamol induced hepatotoxicity. The hepatoprotective activity of Somanathi Tamra Bhasma was tested against paracetamol induced hepatotoxicity in albino rats. The degree of protection was determined by measuring levels of serum marker enzymes like serum glutamate oxaloacetate transminase (SGOT), Serum glutamate pyruvate transminase (SGPT), alkaline phosphate (ALP) etc., and histopasthological studies. Silymarin was used as standard drug for comparison. Administrationof Somanathi Tamra Bhasma (67.5 mg/1kg. Bd. Wt.) markedly prevented paracetamol induced elevation of levels of SGOT, SGPT and alkaline phosphate etc,. The results are comparable to that ofsilymarin. A comparative histopathological study of liver exhibited almost normal architecture as compared to control group. Treatment with Somanathi Tamra Bhasma significantly reduced the paracetamol induced hepatotoxicity. A comparative histological study of liver from different groups further confirmed the hepatoprotective activity of Somanathi Tamra Bhasma.
Authors and Affiliations
Sudheendra Honwad, T. Shridhara Bairy, Ravi M. , B. Ravishankar
Keywords
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