Hepatoprotective models and screening methods: a review
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2014, Vol 2, Issue 9
Abstract
Liver, the largest organ in the body is being evolved to maintain the body’s internal milieu and also protect itself from the challenges it faces during its implementation. It is a essential organ having assorted functions. It theater a significant position not only in the metabolism, production and storage other than in the detoxification of a lot of endogenous and exogenous compounds and converting them to less toxic substances for excretion. A number of herbal preparations are available in the market Liver cell injury caused by a range of toxic chemicals (certain chemotherapeutic agents, anti-biotic, carbon tetrachloride (CCL4), paracetamol (PCM), thioacetamide (TAA) etc.), excessive alcohol consumption and microbes is well-studied. The present review is aimed on liver, its function, liver diseases, types of drug induced hepatotoxicity and their mechanisms of liver damage and clinical scenario.
Authors and Affiliations
Rajesh Asija| Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur-302020, Rajasthan, India., Vijay Kumar| Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur-302020, Rajasthan, India., Pravesh Kumar Sharma| Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur-302020, Rajasthan, India., Radheshyam kumawat| Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur-302020, Rajasthan, India., Aakash Yadav| Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur-302020, Rajasthan, India.
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