Hepatotoxicity Studies of Nimesulide in Litters of Rat
Journal Title: National Journal of Integrated Research in Medicine - Year 2011, Vol 2, Issue 1
Abstract
Present study was carried out to evaluate hepatotoxicity of nimesulide by single dose and seven days administration in sub therapeutic, therapeutic and supra therapeutic doses in litters of rat. Single dose and seven days administration hepatotoxicity studies of nimesulide were carried out in litters of rat of either sex. They were further subdivided into sub therapeutic (20 mg/kg), therapeutic (30 mg/kg) and supra therapeutic (100 mg/kg) groups. Effect of nimesulide on liver functions were analysed by serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and The present study indicates that nimesulide causes significant hepatotoxicity in litters of rat. histopathological examination of liver through scoring system. Histopathological changes in liver were observed in therapeutic and supra therapeutic doses in single dose groups and sub therapeutic, therapeutic and supra therapeutic doses in seven days groups. In single dose of nimesulide in litters, there were significant increases in biochemical parameters (p< 0.05) in supratherapeutic doses. However, in seven days studies of nimesulide in litters, there were significant increases in biochemical parameters (p< 0.05) in therapeutic and supratherapeutic doses.
Authors and Affiliations
Parvati B. Patel*, Tejas K. Patel**, Sunil Patni@, Seema N. Baxi#, Hari Om Shrma@@, C. B. Tripathi***
Keywords
Related Articles
- EP ID EP102745
- DOI -
- Views 144
- Downloads 0
Involvement of Autonomic Nervous System in Isometric Handgrip in Healthy Young Subject
Background: HRV can be considered a relatively simple, noninvasive and sensitive method for studying autonomic modulation, purpose of the present study was to determine whether readily measured blood pressure (BP) ind...
Application Based Learning Through Hospital Projects For Teaching Microbiology To Medical Students
Microbiology in-spite of being a crucial subject for understanding the basic principles with their application in infectious disease fails to impress the undergraduate medical students probably because they are taught...
Prevalence of Uropathogens In Various Age Groups & Their Resistance Pattern In A Tertiary Care Hospital In Central India
Background: The prevalence of multidrug resistance among uropathogens in rapidly increasing. Analysis of the prevalence in various age groups and the common antimicrobial co-resistance pattern of uropathogens isolated...
Serum - Ascites Albumin and Cholesterol Gradients in Differential Diagnosis of Ascites
Background: Differential diagnosis of ascites is a common clinical problem. Less expensive biochemical techniques are required to differentiate ascites with unknown etiology. Aim: To evaluate the diagnostic efficiency...
Prevalence of HIV, Hepatitis B and Hepatitis C infection in Thalassemia major patients in tertiary care hospital, Gujarat.
Background: Children suffering from beta thalassemia major, due to various genetic defects, have deficient synthesis of ß globin chain of Hemoglobin. This leads to severe anemia, general fatigue and debility asking for...