Hidradenitis suppurativa/Acne inversa – etiopathogenesis, clinical presentation and therapeutic options
Journal Title: Postępy Nauk Medycznych - Year 2012, Vol 25, Issue 10
Abstract
Hidradenitis suppurativa/acne inversa (HS) is a chronic recurrent inflammatory skin disease affecting mainly the intertriginous areas. Cutaneous nodules, abscesses, subsequent widespread deep inflammation, sinus tract and fistulas formation with foul-smelling purulent discharge are the main clinical features of the disease. Etiology of HS is believed multifactorial and not clear, but the cigarette smoking and obesity are the established triggering factors.<br>Pathogenesis is not well understood yet. The primary event is a follicular occlusion with secondary inflammation, infection and destruction of the pilosebaceous unit and extension of inflammation to the adjacent subcutis. Treatment depends upon the clinical stage of the disease. There are various therapeutic options known, including antibiotics, antiandrogens, retinoids, systemic corticosteroids, TNF inhibitors, inmmunosupresive/anti-inflammatory agents, all of them used with limited results. The most effective treatment is the radical wide excision of the affected area. Due to its chronicity, recurrent character and specific multifocal embarrassing location HS is physically, psychologically and socially disabling condition with considerable impairment of the quality of life.
Authors and Affiliations
Grażyna Chodorowska
Keywords
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