High frequency of methicillin-susceptible and methicillin-resistant Staphylococcus aureus in children under 1 year old with skin and soft tissue infections
Journal Title: Jornal de Pediatria - Year 2018, Vol 94, Issue 4
Abstract
Objective Staphylococcus aureus is responsible for a large number of infections in pediatric population; however, information about the behavior of such infections in this population is limited. The aim of the study was to describe the clinical, epidemiological, and molecular characteristics of infections caused by methicillin-susceptible and resistant S. aureus (MSSA–MRSA) in a pediatric population. Method A cross-sectional descriptive study in patients from birth to 14 years of age from three high-complexity institutions was conducted (2008–2010). All patients infected with methicillin-resistant S. aureus and a representative sample of patients infected with methicillin-susceptible S. aureus were included. Clinical and epidemiological information was obtained from medical records and molecular characterization included spa typing, pulsed-field gel electrophoresis (PFGE), and multilocus sequence typing (MLST). In addition, staphylococcal cassette chromosome mec (SCCmec) and virulence factor genes were detected. Results A total of 182 patients, 65 with methicillin-susceptible S. aureus infections and 117 with methicillin-resistant S. aureus infections, were included in the study; 41.4% of the patients being under 1 year. The most frequent infections were of the skin and soft tissues. Backgrounds such as having stayed in day care centers and previous use of antibiotics were more common in patients with methicillin-resistant S. aureus infections (p≤0.05). Sixteen clonal complexes were identified and methicillin-susceptible S. aureus strains were more diverse. The most common cassette was staphylococcal cassette chromosomemec IVc (70.8%), which was linked to Panton–Valentine leukocidin (pvl). Conclusions In contrast with other locations, a prevalence of infections in children under 1 year of age in the city could be observed; this emphasizes the importance of epidemiological knowledge at the local level.
Authors and Affiliations
Judy Natalia Jiménez
Keywords
Related Articles
- EP ID EP489358
- DOI 10.1016/j.jped.2017.06.020
- Views 90
- Downloads 0
Association between gestational age and birth weight on the language development of Brazilian children: a systematic review
Objective To review the literature that addresses the relationship between prematurity, birth weight, and development of language in Brazilian children. Sources A systematic review of studies published between 2003 and...
Brain-focused care in the neonatal intensive care unit: the time has come
Survival rates for extremely preterm infants and for critically ill term newborns have improved steadily over the last several decades; however, these same babies continue to experience high rates of adverse neurodevelop...
Brazilian pediatric research groups, lines of research, and main areas of activity
Objectives The Brazilian scientific production in the pediatrics field has been increasing significantly. It is important to identify the distribution and activity of these groups in the country and the main study areas,...
Neonatal screening: 9% of children with filter paper thyroid-stimulating hormone levels between 5 and 10μIU/mL have congenital hypothyroidism
Objectives To determine the prevalence of congenital hypothyroidism in children with filter-paper blood-spot TSH (b-TSH) between 5 and 10μIU/mL in the neonatal screening. Methods This was a retrospective study including...
Post-infectious bronchiolitis obliterans in children: is general quality of life the right measure?
In recent years, the long-term survival of many chronic progressive pulmonary diseases has improved; with such progress, the attention has also shifted from strictly focusing on physiological measurements of lung functio...