High immunoexpression of progesterone-induced blocking factor (PIBF) in endometrial cancer

Journal Title: European Journal of Gynaecological Oncology - Year 2019, Vol 40, Issue 1

Abstract

Purpose of Investigation: This study aims to investigate PIBF expression levels in normal, hyperplastic, and endometrioid adenocarcinoma paraffin blocks. The purpose of this study is to determine the PIBF expression levels in endometrial cancer cells. Materials and Methods: A total of 90 patients were investigated. Thirty of those were diagnosed as having normal endometrial tissue, 30 had endometrial hyperplasia, and 30 had endometrioid adenocarcinoma. The expression of PIBF was assessed using immunohistochemically using paraffin-embedded tissue blocks. Results: Tissue sections were compared based on immunostaining with PIBF. The authors detected higher stromal PIBF expression in the endometrioid adenocarcinoma group as compared to the endometrial hyperplasia and normal endometrium groups (p < 0.001). The glandular PIBF expression did not differ among the groups (p > 0.05). Conclusions: Endometrial cancer cells have higher levels of expression of PIBF protein than normal endometrial tissue and endometrial hyperplasia tissue based on immunohistochemistry staining. PIBF immunostaining may be helpful in preoperatively differentiating between atypical endometrial hyperplasia (AEH) and endometrioid adenocarcinoma (EC) in suspicious cases.

Authors and Affiliations

E. Sahin, Y. Madendag, M.E. Sahin, I. C. Madendag, A. T. Tayyar, F. Senel, H. Karaman, G. Acmaz

Keywords

Related Articles

Risk of cervical cancer and squamous intraepithelial lesions according to human papillomavirus high-risk serotypes detected by qualitative real-time in vitro PCR

Purpose of investigation: To establish the relationship between high-risk human papillomavirus (hrHPV) serotypes and the odds of developing cervical intraepithelial lesions. Material and Methods: Retrospective cohort stu...

Surgical management of recurrent gynecological cancer: Complete resection is the key to longer survival

Summary Purpose of investigation: This study was conducted to elucidate the efficacy and feasibility of surgical management of recurrent gynecological (cervical, endometrial, and ovarian) cancers. Materials and Methods:...

The role of erythropoietin and erythropoietin receptor expression in breast cancer

Erythropoietin (EPO) plays a number of important functions in the body. Contrary to original beliefs, its activity is not limited to exerting effects on cells along the erythropoietic pathway. Newly published results con...

Taraxacum officinale extract induces antitumorigenic effects in ovarian carcinoma cell lines

Purpose of Investigation: Patients suffering from ovarian cancer often use mistletoe preparations in combination with Taraxacum officinale (dandelion) extracts as supplementary therapy to conventional medicine. However,...

The association of microcystic, elongated, and fragmented (MELF) invasion pattern in endometrial carcinomas with prognostic factors

Purpose: One of the most important prognostic factors for endometrial carcinoma (EC) is myometrial invasion. Microcystic, elongated, and fragmented (MELF) myometrial invasion (MI) pattern is also important in terms of di...

Download PDF file
  • EP ID EP663033
  • DOI 10.12892/ejgo4338.2019
  • Views 82
  • Downloads 0

How To Cite

E. Sahin, Y. Madendag, M. E. Sahin, I. C. Madendag, A. T. Tayyar, F. Senel, H. Karaman, G. Acmaz (2019). High immunoexpression of progesterone-induced blocking factor (PIBF) in endometrial cancer. European Journal of Gynaecological Oncology, 40(1), 80-83. https://www.europub.co.uk/articles/-A-663033