High Prevalence of Hypocholesterolaemia among Antiretroviral Therapy-naive HIV-infected Children in Makurdi, Nigeria: A Retrospective Study
Journal Title: International Journal of TROPICAL DISEASE & Health - Year 2014, Vol 4, Issue 11
Abstract
Aim: To determine the abnormalities in total cholesterol (TC) levels and the potential risk factors in ART–naive, HIV-infected Nigerian children. Study Design: A retrospective and cross-sectional study. Place and Duration of Study: Paediatric antiretroviral therapy (ART) clinic of the Federal Medical Centre, Makurdi, between June 2010 and June 2012. Methods: Electronic data of 429 HIV-infected ART-naive children, aged 1–15 years, including 223 males and 206 females, were analysed to get the relevant information for the study. Abnormal un-fasted TC levels and the association with potential risk factors were tested in bivariate regression analyses. Abnormal lipid level was defined as hypercholestrolaemia when the TC was>200mg/dL and hypocholesterolaemia when TC was ˂160mg/dl. Normal TC was value between 160 and 200mg/dl. P-value less than 0.05 was significant. Results: The median age was 5.00 years with an interquartile range of 3.0 to 8.0 years. The TC ranged from 32 to 196 mg/dl with a mean value of 116±34.98mg/dl. Hypocholesterolaemia was the prominent finding in 88.3% (379/429) of the children. Hypercholestrolaemia was not found (0%). In bivariate analyses, no factor was found to significantly impact on hypocholesterolaemia, although a greater proportion of hypocholesterolaemia was seen in children: within 2-15 years age group (92.1%, 349/379); male gender (52.0%): HIV/AIDS stages 1&2 (82.6%); CD4 count>200 cell/mm3(81.5%); viral load>10,000 copies/ml (69.1%); hemoglobin˂10g/dl (61.7%); stunting (55.4%, 102/207) and undernourishment with body mass index (BMI)˂18.5 (83.7%, 164/222). Multivariate analysis was not done. Conclusion: A high prevalence of hypocholesterolaemia was found among the ART-naive, HIV-infected Children, in Makurdi. The study could serve as a stimulus for our centre and other paediatric ART programmes in Nigeria to undertake an elaborate lipid profile of HIV infected children at diagnosis and on follow-up on ART.
Authors and Affiliations
Emmanuel Ademola Anigilaje, Ayodotun Olutola
Keywords
Related Articles
- EP ID EP343376
- DOI 10.9734/IJTDH/2014/11523
- Views 50
- Downloads 0
Factors Affecting Discordance between Sputum Smear and Culture Conversion Rates In Newly Diagnosed Pulmonary Tuberculosis: A Retrospective Study in Developing Country
Aims: To assess the performance of sputum AFB smear for monitoring treatment response and outcome of anti-tuberculous drugs among newly diagnosed smear positive pulmonary TB patients. Study Design: This study was conduct...
Seroincidence of Human Herpes Virus 2 Among Ante-natal Clinic Attendees in Benin, Nigeria
Background: Human Herpes Virus 2 (HSV-2) infection has been shown to be significantly associated with several obstetric complications, especially if the infection occurred during the pregnancy. Advocacy for policy formul...
Herbal Medicines Used in the Treatment of Typhoid in the Ga East Municipality of Ghana
In Ghana, majority of the people patronize herbal medicines for the treatment of both chronic and acute ailments as well as infectious and non-infectious diseases. As such, the use of herbs as medicines in the treatment...
Hepatic Hydrothorax in Patients with Decompensated Cirrhosis in Zagazig University Hospitals: A Cross-sectional and Single Center Study
Background and Study Aim: Hepatic hydrothorax is the presence of more than 500 ml of pleural effusion in a patient with liver disorder. The work aimed to study the frequency of Hepatic hydrothorax in patients with decomp...
Assessment of Training on Acute Flaccid Paralysis Surveillance among Surveillance Officers in Ondo State, Nigeria
Aim: We assessed the immediate impact of Acute Flaccid Paralysis (AFP) surveillance training on the knowledge of AFP surveillance among AFP surveillance personnel, and identify factors associated with changes in knowledg...