Histogenesis of Human Adenohypophysis and Differentiation of Corticotrophs and Thyrotrophs
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 12
Abstract
The pituitary gland is the master endocrine gland which has a complex embryological origin from Rathke’s pouch and diencephalon. [1] They contribute to form two main parts of the gland namely adenohypophysis and neurohypophysis. The functional role of pituitary in the development of other glands is crucial. The appearance and differentiation of various cells in the gland have implications on the overall development and function of different organ systems. The studies carried out on histogenesis of pituitary show varying results and confusion in identification of various cells. [2] The contributing factors may be lack of availability of suitable material and specific staining methods. Many authors have tried to elaborate different methods for the study of histogenesis of pituitary gland. The adenohypophysis especially has chromophobe and chromophil cells having different appearance, staining properties and functional significance. [3] There are studies wherein staining methods are mentioned however most of the studies are carried out on animals. [4]There is paucity of recent data on histogenesis of adenohypophysis at increasing gestational ages. This study aims at describing in detail the development of pituitary gland with special focus on adenohypophysis. The study mainly helps in identifying the various cells in adenohypophysis using H&E stain and a special stain. The study helps to identify the cells as well as the exact time of appearance of the cells throwing light on the stepwise differentiation of adenohypophysis until it assumes the adult architecture by 30 weeks of gestation. The knowledge of histogenesis of adenohypophysis will definitely help to correlate with the histogenesis and functional activity of other glands. The background of histogenesis will help in a better understanding of certain congenital anomalies and pathological conditions with altered architecture of the gland.
Authors and Affiliations
Anandi Neel Bande
Keywords
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