Histological Evaluation of the Effect of Tamra Bhasma (Copper Based Metallic) and Jasada Bhasma (Zinc Based Mineral) Formulations on Testis of Wistar Albino Rats
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 12
Abstract
ABSTRACT Introduction: The metallic or herbo-mineral preparations used in the Indian system of medicine may cause a toxic effect on mammalian tissues. The broad therapeutic usage of these formulations in the form of Bhasmas is required to be ascertained for any adverse effects on the reproductive system. Aim: Present study was undertaken to evaluate the toxic effects of Tamra Bhasma and Jasada Bhasma on male gonads using Wistar albino rats. Materials and Methods: The experimental animals were divided into five different groups comprising of five male rats in each group. Group-I rats were used as the control. Group-II rats received Tamra Bhasma at a Therapeutic Dose (TED). Group-III rats received Tamra Bhasma at five times of therapeutic dose (TED×5). Group-IV rats received Jasada Bhasma at a therapeutic dose (TED), and Group-V rats received Jasada Bhasma five times of therapeutic dose (TED×5) for 28 days. The testes were harvested from these rats, the gross weight of each testes was noted and further processed for histological studies. Results: Testes of the experimental rats treated with both Bhasmas at therapeutic dose level did not show toxicity changes histologically. However, upon the exposure to a higher therapeutic (TED×5) level, it did show the histological features with the indication of decreased spermatogenesis. Conclusion: Test drugs were relatively safer and did not produce any marked toxic effect. However, at higher doses both drugs may produce toxicity on the testis. The higher dose used in the present study was much higher than routinely practiced clinical doses. Therefore, dose-dependent usage of these Bhasmas is recommended.
Authors and Affiliations
Ravi Bhaskar, Megha A Doshi, S Anjana, Shakunthala R Pai, B Ravishankar, Naveen Kumar, Savitha Hemalatha
Keywords
Related Articles
- EP ID EP524601
- DOI 10.7860/JCDR/2018/38377.12437
- Views 97
- Downloads 0
Green Hospital Initiative by a North Delhi Tertiary Care Hospital: Current Scenario and Future Prospects
Introduction: Climate change is likely to affect all forms of life. Healthcare professionals and planners are gearing up to shoulder responsibility to mitigate climate change. The present study was undertaken to explore...
Reversible Cerebral Vasoconstriction Syndrome in a Young Female: A Case Report
ABSTRACT Reversible Cerebral Vasoconstriction Syndrome (RCVS) is a syndrome mimicking diverse clinical and radiological conditions. Pathologically there is altered cerebral vascular tone without histological evidence of...
Head Circumference and Birth Length as Predictor of Low Birth Weight among Bengali Hindu Population of Kolkata, West Bengal, India
ABSTRACT Introduction: Low Birth Weight (LBW) is an important decisive factor for most of the neonatal deaths, hence, Birth Weight (BW) is essential to identify immediately after birth for neonate survival and post-natal...
Dengue Stings the Eye!
Dengue is a vector borne viral fever and has varied ocular affections. We report two cases of Dengue Associated Maculopathy (DAM). The first patient was a 22-year-old lady with dengue fever, presented with diminution of...
Laparoscopic Bariatric Surgery of Super-obese Patient with Intractable Anterior Abdominal Wall Cellulitis: A Rare Challenge to Anaesthesiologist
Obesity has become an epidemic problem worldwide. Obesity and its related comorbidities present a variety of challenges to anaesthesiologist. Bariatric surgery is the best treatment modality for patients who do not respo...