Histomorphological Spectrum of Nephrectomy Specimens- A Tertiary Care Centre Experience
Journal Title: National Journal of Laboratory Medicine - Year 2016, Vol 5, Issue 2
Abstract
ABSTRACT Introduction: Nephrectomy is a common surgical procedure done for a variety of neoplastic and nonneoplastic diseases. This study has been taken up to analyze kidney diseases histopathologically and various lesions of the kidney and their subtypes and record the various lesions which lead to partial nephrectomy, total nephrectomy, unilateral and bilateral nephrectomies. Aim: To study spectrum of diseases in nephrectomy specimens, histological subtyping of neoplastic conditions and evaluation of histopathological prognostic features like capsular invasion, vascular invasion and nuclear grade. Materials and Methods: This was a retrospective and prospective analysis done over the period of 4 years (2006-2009). A nephrectomy specimens received in the Department of Pathology Dayanand Medical College and Hospital, Ludhiana were analyzed with respect to gross and microscopic features. Results: Out of a total number of 155 cases, 82 were neoplastic, 73 were non-neoplastic. Males were 98 and females 57 with a M:F ratio 1.7:1. Out of the 82 neoplastic cases, Renal cell carcinoma (Clear cell type) was commonest (57 cases) followed by Transitional cell carcinoma (07 cases), Papillary RCC (03 cases), Oncocytoma (03 cases), Wilm’s tumour (02 cases), RCC with sarcomatoid change (02 cases), RCC unclassifiable (03 cases) and 01 case each of Chromophobe RCC, Multicystic RCC, Collecting duct carcinoma, small round cell tumour and transitional Cell Carcinoma respectively. Of the 73 non-neoplastic cases, chronic pyelonephritis with hydronephrosis constituted 42 cases, emphysematous pyelonephritis (16 cases), xanthogranulomatous pyelonephritis (02 cases), acute or chronic pyelonephritis (09 cases), polycystic kidney (02 cases), cystic renal dysplasia and tuberculosis (01 case each). Conclusion: Radical nephrectomy is the common surgical procedure done for both neoplastic disorders as well as non neoplastic lesions. Detailed histopathological examination is necessary for diagnosis and the prognostication of the lesions.
Authors and Affiliations
Dr Vikram Narang, Dr Bhavna Garg, Dr Ashneet Walia, Dr Neena Sood, Dr Vineeta Malhotra
Keywords
Related Articles
- EP ID EP379094
- DOI 10.7860/NJLM/2016/18261:2112
- Views 136
- Downloads 0
Role of Fine Needle Aspiration Cytology in the Assessment of Intra-Abdominal and Retroperitoneal Lesions-A Comparative Study
Introduction: Fine needle aspiration cytology (FNAC) is a widely used valuable, accurate, and safe method which was initially applied only for readily palpable masses.But in recent years previously inaccessible lesions a...
Inter-Observer Variation in Reporting of Pap Smears
Introduction: The Papanicolaou smear is one of the most important tests in preventive health care which helps to identify women at risk of developing cervical cancer. The use of the test is increasing because of more awa...
Study on Drug Resistant Pulmonary Tuberculosis using Line Probe Assay in a Tertiary Care Hospital from Eastern India
Introduction: Pulmonary Tuberculosis (PTB) is a major public health issue globally, all age groups in community are at high risk to become get infected. Multidrug Resistant (MDR) and extensively drug resistant Mycobacter...
Immunophenotypic and Morphological Profile of Basal like and non Basal like Invasive Breast Carcinoma
Introduction: Breast carcinomas are heterogeneous disease with different prognosis and therapy responses despite similarities in histological types, grade and stage. Recently, gene expression profiling, a method using cD...
Study of Correlation of Serum Thyroid Hormones with Plasma Insulin and Insulin Resistance Index in Patients of Hypothyroidism
Introduction: Hypothyroidism, a condition of hyposecretion of T3 and T4 with high TSH is associated with hyperinsulinaemia and increased insulin resistance index due to disturbances in insulin secretion with deranged lip...