Histopathological Spectrum of Premalignant and Malignant Lesions of Uterine Cervix
Journal Title: National Journal of Laboratory Medicine - Year 2018, Vol 7, Issue 1
Abstract
ABSTRACt Introduction: Cervical cancer is the most common cancer in Indian women and arises after many years from morphologically defined precancerous lesions. There is a considerable variation in diagnostic criteria for intraepithelial neoplasia and microinvasion also, in cases of frank malignancy histomorphological study helps in typing lesion, establishing stages of development and extent of involvement which is critical for prognostication and clinical management. Aim: To study the histomorphological features of premalignant and malignant lesions of the uterine cervix and categorise them into various types based on microscopy. Materials and Methods: The study included all histologically proven premalignant and malignant lesions of the uterine cervix. They were categorised into different types based on the World Health Organisation classification and associated morphological features were studied. Results: There were 36 premalignant and 74 malignant lesions of the uterine cervix. Cervical Intraepithelial Neoplasia (CIN) 1 was diagnosed in 36.1% patients, followed by CIN 2 (33.3%) and CIN 3 (30.6%). Amongst the malignant lesions, squamous cell carcinoma was the most common lesion encountered in 85.1% cases. There was a progressive increase in mean age of diagnosis from CIN 1 to invasive carcinoma. Other malignant lesions encountered were adenocarcinoma (8.1%), adenosquamous carcinoma (1.3%) and neuroendocrine carcinoma (5.4%). Conclusion: Cervical cancer continues to be the most common cancer of females in developing countries. Histopathological examination is considered gold standard for diagnosis of intraepithelial neoplasia and cervical carcinoma and should be attempted at an early stage to provide better prognosis, treatment and protection against invasive cervical carcinoma.
Authors and Affiliations
Mamta Gupta, PK BASAVARAJ
Keywords
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- EP ID EP528891
- DOI 10.7860/NJLM/2018/32340:2276
- Views 152
- Downloads 0
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