HIV antiretroviral therapy among blood donors: the impact on blood safety

Journal Title: Chinese Journal of Blood Transfusion - Year 2024, Vol 37, Issue 2

Abstract

Objective To explore the the potential risks of antiretroviral therapy(ART) drugs on blood safety among blood donors in Shenzhen. Methods High pressure liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS) was used to measure ART drugs concentrations in the plasma of regular blood donors (negative control group, n=86) and anti-HIV positive individuals (experimental group, n=98, detected from approximately 440 000 blood donors during 2019—2023). The baseline plasma concentrations of ART drugs in the negative control group were clarified, and the impact of ART drugs on blood safety was analyzed. Results The baseline concentrations of ART drugs were not detected in 86 samples of negative control group. Four positive ART drugs samples were detected in 1∶2 pooled plasma samples of 98 anti-HIV positive blood donors plasma in the resolution test. The ART positive rate of anti-HIV positive donors was 4.08%, with tenofovir, lamivudine and efavirenz detected in three blood donors and lamivudine, lopinavir, ritonavir and zidovudine detected in one blood donor. Conclusion ART drugs were found among anti-HIV positive blood donors in Shenzhen. Additional research is needed to investigate the motivation of these specific donors, so as to ascertain the groups most susceptible to potential risks, and guarantee blood safety.

Authors and Affiliations

Lilin WANG, Fang ZHAO, Zhengrong YANG, Rui ZHU, Yizhong LIU, Linfeng WU, Tong LI, Tingting CHEN, Jinfeng ZENG

Keywords

Related Articles

Investigation on current Hepatitis E virus infection among voluntary blood donors

Objective To investigate the situation of hepatitis E virus(HEV) infection among voluntary blood donors in Wuhan area and provide evidences for enhancing blood screening strategies. Methods HEV nucleic acid detection(NAT...

Cost-benefit analysis of hepatitis B virus serological and nucleic acid testing in blood donors

Objective In an effort to prevent transfusion-transmitted hepatitis B infection, universal HBsAg screening, HBsAg+ MP nucleic acid test(NAT) for HBV and HBsAg + individual(ID) NAT were analyzed for cost-effectiveness. Me...

Application of MALDI-TOF MS in clinical difficult blood group typing

Objective To explore the application of matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) in the genotyping of difficult blood typing samples, and to provide evidence for clinica...

Inhibitory effect of Salidroside on the interaction between human platelets and breast cancer MDA-MB-468 cells

Objective To study the effect of Salidroside(Sal) on platelet activation and aggregation and the interaction between human platelets and MDA-MB-468 cells of breast cancer. Methods Human platelets were collected, platelet...

HIV screening results of college group blood donors in Tianjin from 2012 to 2021

Objective To analyze the infection characteristics and prevalence of HIV among college group voluntary blood donors in Tianjin, China, so as to provide data support for improving the promotion and recruitment strategies...

Download PDF file
  • EP ID EP738757
  • DOI 10.13303/j.cjbt.issn.1004­549x.2024.02.003
  • Views 54
  • Downloads 0

How To Cite

Lilin WANG, Fang ZHAO, Zhengrong YANG, Rui ZHU, Yizhong LIU, Linfeng WU, Tong LI, Tingting CHEN, Jinfeng ZENG (2024). HIV antiretroviral therapy among blood donors: the impact on blood safety. Chinese Journal of Blood Transfusion, 37(2), -. https://www.europub.co.uk/articles/-A-738757