Homeostatic Synaptic Plasticity: Balanced by COX2-PGE2 System to a New Setpoint
Journal Title: Science Insights - Year 2013, Vol 1, Issue 2
Abstract
The setpoint of neural activity plays a critical role in maintaining the complex neural circuits into stable activities. Homeostatic synaptic plasticity is a major component of the setpoint theory that dynamically adjusts synaptic strengths. Cyclooxy-genase 2 (COX 2) is rapidly upregulated in inflammatory episodes after nervous injury and its product prostaglandin E2 (PGE2) exerts contrast functions in the nervous system by working on the homeostatic plasticity. New data revealed that COX2-PGE2 system takes an essential part in balancing excitation and inhibition of the synaptic activities at a new setpoint that finally is maintained by the homeostatic synaptic plasticity.
Authors and Affiliations
Fuzhou Wang
Keywords
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- EP ID EP689527
- DOI 10.15354/si.13.ar004
- Views 216
- Downloads 0
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