Human Papilloma Virus as one of the etiological factor for oral Squamous Cell Carcinoma-an Updated Review
Journal Title: Pakistan Biomedical Journal - Year 2018, Vol 1, Issue 1
Abstract
Human papilloma virus (HPV) related head and neck squamous cell cancer (HNSCC) has varying etiology, genetic as well as environmental factors involved and differential clinicicopathological features. HNSCC came in the limelight recently due to increased incidence rate and insouciant diagnostic methods. This review will comprehensively focus on the characteristics of HPV associated HNSCC. It will provide an updated review of our understanding of HPV role in Oral squamous cell carcinoma (OSCC) known to date. Currently, three vaccines are available (Gardasil, Gardasil 9 and Cervarix). These vaccines prevent infections with HPV types 16 and 18 HPV-16 is most common type associated with HNSCC. HPV related HNSCC has better prognosis, does not mutate but inactivates tumor suppressor genes and therefore has comparatively better treatment options. However, there is still a need to improve our methods of sampling, HPV molecular assay and type of specimen to be used.
Authors and Affiliations
Jaspreet Kaur
Keywords
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- EP ID EP694159
- DOI https://doi.org/10.52229/pbmj.v1i1.37
- Views 169
- Downloads 0
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