Hyperglycaemia and Inflammation are culprits of late diabetic complications
Journal Title: Archives of Medical Science - Year 2005, Vol 1, Issue 2
Abstract
Hyperglycaemia and the inflammatory process play a crucial role in the development of late diabetic complications. In hyperglycaemic conditions glucose metabolism is enhanced in both main and alternative pathways. It results in enhanced glycation of proteins, glucose autoxidation and overproduction of reactive oxygen species (ROS). Metabolic disturbances lead to activation of protein kinase C (PKC) and nuclear factor kappa B (NF-kB). NF-kB is a transcription factor that itself activates many proinflammatory genes in the vasculature. Traditional risk factors such as elevated LDL cholesterol, low HDL cholesterol level, smoking, hypertension and hyperglycaemia do not fully explain the marked increase in mortality associated with diabetes and its complications. Many novel factors, named non-traditional cardiovascular disease risk factors, have been proposed recently as potentially important predictors of coronary heart disease both in general and diabetic population. Most of them are characteristic of the inflammatory process and reflect intensity of inflammation although experimental, clinical and epidemiological studies suggest that some processes related to low-grade inflammation may be relevant to diabetic micro- and macroangiopathy, further large-scale observational studies and randomized intervention studies of “anti-inflammatory” interventions will be needed to elucidate the meanings of these associations.
Authors and Affiliations
Dorota Zozulińska, Bogna Wierusz-Wysocka
Keywords
Related Articles
- EP ID EP107354
- DOI -
- Views 178
- Downloads 0
Diagnosis and treatment of chronic lymphocytic leukaemia: practical remarks
The preventive role of coenzyme Q10 and other antioxidants in injuries caused by oxidative stress
Episodes of severe menorrhagia at menarche in a girl with von Willebrand disease
We describe a case of a 14-year-old girl with von Willebrand disease (vWD) and episodes of severe menorrhagia at menarche, necessitating hospitalization and requiring blood transfusions and administration of purified von...
Glucose metabolism in conventionally treated patients with b-thalassaemia major assessed with oral glucose tolerance test
Neopterin and circulating adhesion molecules as prognostic markers in childhood asthma
Introduction: The purpose of this study was to determine the serum levels of neopterin and circulating adhesion molecules sICAM-1, sE-selectin and sL-selectin in children with stable asthma in order to investigate thei...