Hypothalamus-pituitary-thyroid axis activity and function of cardiac muscle in energy deficit
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2017, Vol 71, Issue
Abstract
Frequently repeated statement that energy restriction is a factor that improves cardiovascular system function seems to be not fully truth. Low energy intake modifies the hypothalamus-pituitary-thyroid axis activity and thyroid hormone peripheral metabolism. Thyroid hormones, as modulators of the expression and activity of many cardiomyocyte proteins, control heart function. Decreased thyroid hormone levels and their disturbanced conversion and action result in alternation of cardiac remodeling, disorder of calcium homeostasis and diminish myocardial contractility. This review provides a summary of the current state of knowledge about the mechanisms of energy restriction effects on thyroidal axis activity, thyroid hormone peripheral metabolism and action in target tissues, especially in cardiac myocytes. We also showed the existence of energy restriction-thyroid-heart pathway.
Authors and Affiliations
Katarzyna Lachowicz, Ewelina Pałkowska-Goździk, Danuta Rosołowska-Huszcz
Keywords
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- EP ID EP248473
- DOI 10.5604/01.3001.0010.7639
- Views 182
- Downloads 0
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