Iatrogenic Baclofen Neurotoxicity in End Stage Renal Disease: A Case Report and Review of Literature
Journal Title: Journal of Advances in Medical and Pharmaceutical Sciences - Year 2016, Vol 10, Issue 1
Abstract
Baclofen is a centrally acting antispasmodic agent that is commonly prescribed to patients suffering from spinal cord problems. Nearly 85% of baclofen is excreted by the kidneys whereas the remaining 15% is metabolized by the liver. In patients with renal insufficiency, baclofen accumulates and causes central nervous system toxicity. Herein we report a case of baclofen induced neurotoxicity in a patient with end stage renal disease on maintenance haemodialysis. The patient had cervical spondylomyopathy and was started on baclofen 10 mg once daily which was subsequently increased to three times a day. Within 48 hours of the increased dose of baclofen, he developed drowsiness, confusion and became aggressive. Other causes of encephalopathy were excluded and baclofen was stopped. His confusion improved completely after three consecutive sessions of haemodialysis. Physicians should be aware of baclofen induced neurotoxicity in patients with renal insufficiency.
Authors and Affiliations
Navaneedha Lingam Mahalingam, Rizna Abdul Cader
Keywords
Related Articles
- EP ID EP328571
- DOI 10.9734/JAMPS/2016/29261
- Views 94
- Downloads 0
Nutritive Composition and Antimicrobial Activity of Moringa stenopetala (Baker f.) Cufod
Aims: The present study was carried out to determine nutritive composition and to screen antimicrobial activity of leaf extract of Moringa stenopetala (Baker f.) Cufod. Place and Duration of the Study: The study was per...
In vitro Comparison of Metronidazole and Tinidazole Activity against Trichomonas vaginalis Strains in Maiduguri, Nigeria
This study investigated the in vitro comparison of metronidazole and tinidazole activity against Trichomonas vaginalis strains from internally displaced women in Maiduguri, Nigeria. Materials and Methodology: high vagina...
The Frequency of CYP3A5 Expression in a Mexican Population Compared to a Caucasian Population
Aims: To determine the frequencies of the six most common CYP3A5 alleles and genotypes in a Mexican-American population compared to a non-Hispanic Caucasian population. Study Design: This cross-sectional study compared...
Prescribing Errors in Nigeria’s Healthcare System; Exploration towards Promoting Rational Prescribing for Improved Patient Care
Rational prescribing is vital to achieving rational drug use but limited studies exist on the prescription practices, causes, and types of prescription error in developing countries. Prescription error is one of the lead...
Molecular Identity and Antimicrobial Profile of Trametes species Collected from the Teaching and Research Farm of the Federal University of Technology, Akure, Nigeria
Aims: The present study investigated the identity, antimicrobial, and secondary metabolites profile of Trametes species collected from forest near the Teaching and Research farm of the Federal University of Technology, A...