Ibuprofen: Original Versus Green Synthesis
Journal Title: Analele Universitatii "Dunarea de Jos" din Galati. Fascicula IX, Metalurgie si Stiinta Materialelor - Year 2018, Vol 41, Issue 3
Abstract
This paper makes a parallel between the original route versus the green route of Ibuprofen (non-steroidal anti-inflammatory drugs most commonly recommended) synthesis. The original route contained six steps with stoichiometric reagents (some reagents are very toxic: hydrochloric acid, ammonia), a lot of intermediate products, relatively low atom efficiency equal to 40.04% and substantial inorganic salt formation (aluminium trichloride hydrate). The green route of Ibuprofen synthesis developed only three steps, a lower amount of waste and by-products (only acetic acid that can be used for another applications) and an atom efficiency of 77.44%. The green route for Ibuprofen synthesis is an exquisite example of a simple and elegant chemical/pharmaceutical manufacturing process and the nearly complete atom utilization of this streamlined process truly makes it a wasteminimizing, environmentally friendly technology.
Authors and Affiliations
Alina Crina MUREŞAN
Keywords
Related Articles
- EP ID EP623275
- DOI 10.35219/mms.2018.3.05
- Views 104
- Downloads 0
Structural Aspects of Antifriction Properties Brass
a + β' brass types with antifriction properties belong to the category of hightensile brass, alloys which besides Cu and Zn also contain certain alloying materials introduced in order to obtain some special characteristi...
Mathematical Modeling of Thermomechanical Treatment Process Applied to Aluminum Base Alloys for Aeronautics
To optimize the thermo-mechanical processing of aluminum base alloys, mathematical modeling was used in a laborious research program by planned experiment of thermomechanical treatment process applied to an Al-Zn system...
Experimental Equation of Deformation Behaviour of a Concrete Steel
The plastic deformation behavior is defined by the function of the deformation strength according to the strain, strain rate and temperature as the factor of the deformation process. The behavior law establishes by the e...
Aspects of Materials Decay Under Chemical Attack from the Leachate Treatment Plant of the Tirighina Waste Landfill
Human society faces a number of major problems among which the increasingly negative consequences of environmental pollution. The high uses rate of the natural resources and the large amount of waste generated tend to tr...
Some Effects of Microwave Heating of Chromite Ore for Fe-CrAl Alloys by Aluminothermy
Processes and prime materials involved in Fe-Cr-Al alloys production by aluminothermy are presented having in view new possibilities to produce them more ecological and more efficient, using energy of microwave field. Th...